Tumor necrosis factor: The key to hepatitis B viral clearance.
作者信息
Chyuan I-Tsu, Hsu Ping-Ning
机构信息
Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan, China.
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, China.
出版信息
Cell Mol Immunol. 2018 Aug;15(8):731-733. doi: 10.1038/cmi.2017.139. Epub 2018 Jan 29.
Abstract
摘要
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Medicine (Baltimore). 2016 Dec;95(50):e5609. doi: 10.1097/MD.0000000000005609.
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TNF biology, pathogenic mechanisms and emerging therapeutic strategies.肿瘤坏死因子的生物学特性、致病机制及新出现的治疗策略。
Nat Rev Rheumatol. 2016 Jan;12(1):49-62. doi: 10.1038/nrrheum.2015.169. Epub 2015 Dec 10.
3
Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.T 细胞产生的干扰素-γ 和肿瘤坏死因子-α 可减少 HBV 持续存在形式 cccDNA，而不引起细胞溶解。
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Cleaved c-FLIP mediates the antiviral effect of TNF-α against hepatitis B virus by dysregulating hepatocyte nuclear factors.裂解的c-FLIP通过失调肝细胞核因子介导TNF-α对乙型肝炎病毒的抗病毒作用。
J Hepatol. 2016 Feb;64(2):268-277. doi: 10.1016/j.jhep.2015.09.012. Epub 2015 Sep 25.
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