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Osteoporos Int. 2015 Oct;26(10):2491-9. doi: 10.1007/s00198-015-3165-3. Epub 2015 May 12.
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Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle.捕获骨折：打破脆性骨折周期的最佳实践框架和全球运动。
Osteoporos Int. 2013 Aug;24(8):2135-52. doi: 10.1007/s00198-013-2348-z. Epub 2013 Apr 16.
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Osteoporos Int. 2013 Jan;24(1):23-57. doi: 10.1007/s00198-012-2074-y. Epub 2012 Oct 19.
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Predictors of treatment with osteoporosis medications after recent fragility fractures in a multinational cohort of postmenopausal women.近期脆性骨折后多国绝经后女性队列中骨质疏松症药物治疗的预测因素。
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The American Orthopaedic Association's "own the bone" initiative to prevent secondary fractures.美国矫形外科协会的“拥有骨骼”预防二次骨折倡议。
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Requirements for DXA for the management of osteoporosis in Europe.欧洲骨质疏松症管理中双能X线吸收法（DXA）的要求。
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诗里拉杰代谢性骨病诊所骨质疏松症和维生素D缺乏症的患病率

PREVALENCE OF OSTEOPOROSIS AND HYPOVITAMINOSIS D AT SIRIRAJ METABOLIC BONE DISEASE CLINIC.

作者信息

Unnanuntana Aasis, Chotiyarnwong Pojchong

机构信息

. Department of Orthopedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Acta Ortop Bras. 2017 Nov-Dec;25(6):262-265. doi: 10.1590/1413-785220172506174133.

DOI:10.1590/1413-785220172506174133
PMID:29375256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5782860/
Abstract

OBJECTIVE

To identify the prevalence of osteoporosis and hypovitaminosis D among patients at the Siriraj Metabolic Bone Disease (MBD) Clinic, and to compare initial vitamin D levels in patients with and without a history of fragility fractures.

METHODS

Medical records of patients who attended our MBD clinic between 2012 and 2015 were retrospectively reviewed. Patient baseline demographic, clinical, bone mineral density (BMD), and laboratory data were collected and analyzed. Osteoporosis was diagnosed when patients had a BMD T-score <-2.5 or presented with fragility fractures.

RESULTS

There were 761 patients included in this study. Of these, 627 patients (82.4%) were diagnosed with osteoporosis and 508 patients (66.8%) had fragility fractures. Baseline serum 25-hydroxyvitamin D (25(OH)D) levels were available in 685 patients. Of these, 391 patients (57.1%) were diagnosed with hypovitaminosis D. When evaluated only in patients with fragility fractures, the average initial 25(OH)D level was 28.2±11.6 ng/mL, and the prevalence of hypovitaminosis D was 57.6%.

CONCLUSION

A high prevalence of osteoporosis and hypovitaminosis D was found among patients at our clinic; two-thirds of patients had a history of fragility fractures, and no difference in initial 25(OH)D levels was seen between patients with and without fragility fractures.

摘要

目的

确定诗里拉吉代谢性骨病（MBD）诊所患者中骨质疏松症和维生素D缺乏症的患病率，并比较有和没有脆性骨折病史患者的初始维生素D水平。

方法

回顾性分析2012年至2015年期间在我们MBD诊所就诊患者的病历。收集并分析患者的基线人口统计学、临床、骨密度（BMD）和实验室数据。当患者的BMD T值＜-2.5或出现脆性骨折时诊断为骨质疏松症。

结果

本研究纳入761例患者。其中，627例患者（82.4%）被诊断为骨质疏松症，508例患者（66.8%）有脆性骨折。685例患者有基线血清25-羟维生素D（25(OH)D）水平数据。其中，391例患者（57.1%）被诊断为维生素D缺乏症。仅在有脆性骨折的患者中评估时，初始25(OH)D平均水平为28.2±11.6 ng/mL，维生素D缺乏症患病率为57.6%。

结论

在我们诊所的患者中发现骨质疏松症和维生素D缺乏症的患病率很高；三分之二的患者有脆性骨折病史，有和没有脆性骨折病史的患者在初始25(OH)D水平上没有差异。