猫和狗下丘脑神经分泌神经元的节律性放电模式。
Rhythmic patterns of discharge in hypothalamic neurosecretory neurons of cats and dogs.
作者信息
Yamashita H, Koizumi K, Brooks C M
出版信息
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6684-8. doi: 10.1073/pnas.76.12.6684.
Recent studies in rats suggest that vasopressin- and oxytocin-secreting neurons in supraoptic nuclei and paraventricular nuclei of the hypothalamus show two different patterns of activity: one a "bursting" or rhythmic pattern and the other, irregular continuous discharges. This possibility was investigated in cats and dogs anesthetized with chloralose or Nembutal by recording electrical activity of single supraoptic and paraventricular neurons. Only some of the "identified" neurosecretory cells showed rhythmic, intermittent discharges ("bursting" cells in rats); the majority showed an irregular continuous firing pattern. Furthermore, the pattern of discharge sometimes changed from one ot the other during long periods of observation. This occurred without apparent stimulus in certain instances; in others, the rhythmic firing was associated with fluctuation in blood pressure and heart rate and was likely to be caused by changes in baroreceptor activity. Possible origins of rhythmic discharges and the physiological importance of such patterns in terms of hormone secretion are discussed.
最近对大鼠的研究表明，下丘脑视上核和室旁核中分泌血管加压素和催产素的神经元表现出两种不同的活动模式：一种是“爆发性”或节律性模式，另一种是不规则的持续放电。通过记录单个视上核和室旁核神经元的电活动，对用氯醛糖或戊巴比妥麻醉的猫和狗进行了此项研究。只有一些“已确定的”神经分泌细胞表现出节律性、间歇性放电（大鼠中的“爆发性”细胞）；大多数细胞表现出不规则的持续放电模式。此外，在长时间观察期间，放电模式有时会从一种模式转变为另一种模式。在某些情况下，这种转变没有明显的刺激；在其他情况下，节律性放电与血压和心率的波动有关，可能是由压力感受器活动的变化引起的。文中讨论了节律性放电的可能起源以及这种模式在激素分泌方面的生理重要性。
Zotero 插件