Mardente Stefania, Mari Emanuela, Massimi Isabella, Tafani Marco, Guerriero Raffaella, Morsilli Ornella, Pulcinelli Fabio M, Bianchi Marco E, Zicari Alessandra
Department of Experimental Medicine, University of Rome Sapienza, Rome, Italy.
Department of Cellular and Molecular Pathology, IRCCS San Raffaele, Rome, Italy.
Front Immunol. 2018 Jan 12;8:1946. doi: 10.3389/fimmu.2017.01946. eCollection 2017.
Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis. Megakaryocytes (MKs) synthesize HMGB1 and transfer both protein and mRNA into PLTs and PLT-derived microvesicles (MV). Free HMGB1 found in supernatants of differentiated MKs and in a megakaryoblastic cell line (DAMI cells). Aspirin "" and "" not only reduces HMGB1 and receptor for advanced glycation end products expression on MKs and PLTs but also drives the movement of HMGB1 from MKs into PLTs and PLT-derived MV. These findings suggest that consumption of low doses of aspirin reduces the risk of atherosclerosis complications as well as reducing PLT aggregation by the inhibition of COX-1.
血小板（PLTs）是高迁移率族蛋白B1（HMGB1）的主要来源，HMGB1是一种参与血管无菌性炎症和血栓形成的蛋白质。巨核细胞（MKs）合成HMGB1，并将蛋白质和mRNA转移到血小板和血小板衍生的微泡（MV）中。在分化的巨核细胞上清液和巨核母细胞系（DAMI细胞）中发现游离的HMGB1。阿司匹林不仅降低巨核细胞和血小板上HMGB1和晚期糖基化终产物受体的表达，还促使HMGB1从巨核细胞转移到血小板和血小板衍生的微泡中。这些发现表明，低剂量阿司匹林的摄入降低了动脉粥样硬化并发症的风险，同时通过抑制COX-1减少血小板聚集。
