• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

经放化疗治愈的转移性人乳头瘤病毒相关口咽癌：治疗前生物分子评估的重要性

Metastatic HPV-related oropharyngeal carcinoma cured with chemoradiotherapy: importance of pretherapy biomolecular assessment.

作者信息

Perri Francesco, Longo Francesco, Della Vittoria Scarpati Giuseppina, Pisconti Salvatore, Longo Vito, Addeo Raffaele, Carducci Fabio, Buonerba Carlo, Fulciniti Franco, Solla Raffaele

机构信息

Medical Oncology Department POC SS Annunziata Taranto Italy.

Otolaryngology Unit National Tumour Institute of Naples, G Pascale Naples Italy.

出版信息

Clin Case Rep. 2017 Nov 24;6(1):56-62. doi: 10.1002/ccr3.1107. eCollection 2018 Jan.

DOI:10.1002/ccr3.1107
PMID:29375838
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5771910/
Abstract

Pretherapy assessment has a crucial role in the management of advanced oropharyngeal carcinoma. The case report represents an example of how translational research may help to optimize the therapeutic options and to choose a well-shaped therapy adapted to the tumor and the patient.

摘要

治疗前评估在晚期口咽癌的管理中起着关键作用。该病例报告展示了转化研究如何有助于优化治疗方案，并选择适合肿瘤和患者的精准治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e74/5771910/db5aec9e6042/CCR3-6-56-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e74/5771910/fb9047d4452d/CCR3-6-56-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e74/5771910/e5ccf2b99c3e/CCR3-6-56-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e74/5771910/db5aec9e6042/CCR3-6-56-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e74/5771910/fb9047d4452d/CCR3-6-56-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e74/5771910/e5ccf2b99c3e/CCR3-6-56-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e74/5771910/db5aec9e6042/CCR3-6-56-g003.jpg

相似文献

1
Metastatic HPV-related oropharyngeal carcinoma cured with chemoradiotherapy: importance of pretherapy biomolecular assessment.经放化疗治愈的转移性人乳头瘤病毒相关口咽癌：治疗前生物分子评估的重要性
Clin Case Rep. 2017 Nov 24;6(1):56-62. doi: 10.1002/ccr3.1107. eCollection 2018 Jan.
2
Potential clinical implications of HPV status and expressions of p53 and cyclin D1 among oropharyngeal cancer patients.人乳头瘤病毒状态及抑癌基因 p53、细胞周期蛋白 D1 在口咽癌患者中的表达及其潜在的临床意义。
J Oral Pathol Med. 2018 Nov;47(10):945-953. doi: 10.1111/jop.12779. Epub 2018 Sep 27.
3
Radiotherapy alone as a possible de-intensified treatment for human papillomavirus-related locally advanced oropharyngeal squamous cell carcinoma.单纯放疗作为人乳头瘤病毒相关局部晚期口咽鳞状细胞癌可能的减量化治疗。
Int J Clin Oncol. 2019 Jun;24(6):640-648. doi: 10.1007/s10147-019-01394-1. Epub 2019 Jan 29.
4
Induction chemotherapy followed by concurrent chemoradiotherapy for advanced stage oropharyngeal squamous cell carcinoma with HPV and P16 testing.对晚期口咽鳞状细胞癌进行人乳头瘤病毒（HPV）和P16检测后，先进行诱导化疗，然后进行同步放化疗。
Ann Otol Rhinol Laryngol. 2014 May;123(5):365-73. doi: 10.1177/0003489414526685. Epub 2014 Mar 31.
5
Molecular subclassification determined by human papillomavirus and epidermal growth factor receptor status is associated with the prognosis of oropharyngeal squamous cell carcinoma.由人乳头瘤病毒和表皮生长因子受体状态所确定的分子亚分类与口咽鳞状细胞癌的预后相关。
Hum Pathol. 2016 Apr;50:51-61. doi: 10.1016/j.humpath.2015.11.001. Epub 2015 Nov 17.
6
Effect of human papillomavirus on patterns of distant metastatic failure in oropharyngeal squamous cell carcinoma treated with chemoradiotherapy.人乳头瘤病毒对接受放化疗的口咽鳞状细胞癌远处转移失败模式的影响。
JAMA Otolaryngol Head Neck Surg. 2015 May 1;141(5):457-62. doi: 10.1001/jamaoto.2015.136.
7
HPV acting on E-cadherin, p53 and p16: literature review.HPV 作用于 E-钙黏蛋白、p53 和 p16：文献综述。
J Biol Regul Homeost Agents. 2018 Jan-Feb;32(2 Suppl. 1):73-79.
8
Analysis of p53, p16(INK4a), pRb and Cyclin D1 expression and human papillomavirus in primary ovarian serous carcinomas.原发性卵巢浆液性癌中p53、p16（INK4a）、pRb和细胞周期蛋白D1表达及人乳头瘤病毒的分析
Exp Oncol. 2011 Sep;33(3):150-6.
9
Use of cyclin D1 in conjunction with human papillomavirus status to predict outcome in oropharyngeal cancer.使用细胞周期蛋白 D1 结合人乳头瘤病毒状态预测口咽癌的预后。
Int J Cancer. 2011 Apr 1;128(7):1532-45. doi: 10.1002/ijc.25479. Epub 2010 May 25.
10
Pathological and Virological Studies of p16-Positive Oropharyngeal Carcinoma with a Good Response to Neoadjuvant Chemotherapy.对新辅助化疗反应良好的p16阳性口咽癌的病理学和病毒学研究
Microorganisms. 2020 Sep 29;8(10):1497. doi: 10.3390/microorganisms8101497.

引用本文的文献

1
Applications for Circulating Cell-Free DNA in Oral Squamous Cell Carcinoma: A Non-Invasive Approach for Detecting Structural Variants, Fusions, and Oncoviruses.循环游离DNA在口腔鳞状细胞癌中的应用：一种检测结构变异、融合和肿瘤病毒的非侵入性方法。
Cancers (Basel). 2025 Jun 6;17(12):1901. doi: 10.3390/cancers17121901.
2
Approach to the Patient with Recurrent/Metastatic Disease.复发性/转移性疾病患者的处理方法。
Curr Treat Options Oncol. 2019 Jun 25;20(8):65. doi: 10.1007/s11864-019-0664-z.

本文引用的文献

1
The Growing Epidemic of HPV-Positive Oropharyngeal Carcinoma: A Clinical Review for Primary Care Providers.人乳头瘤病毒阳性口咽癌的流行趋势日益加剧：基层医疗服务提供者的临床综述
J Am Board Fam Med. 2015 Jul-Aug;28(4):498-503. doi: 10.3122/jabfm.2015.04.140301.
2
Induction chemotherapy with concurrent chemoradiotherapy versus concurrent chemoradiotherapy for locally advanced squamous cell carcinoma of head and neck: a meta-analysis.诱导化疗联合同步放化疗与同步放化疗治疗局部晚期头颈部鳞状细胞癌的Meta分析
Sci Rep. 2015 Jun 4;5:10798. doi: 10.1038/srep10798.
3
Treatment Outcomes for T4 Oropharyngeal Squamous Cell Carcinoma.
T4期口咽鳞状细胞癌的治疗结果
JAMA Otolaryngol Head Neck Surg. 2015 Dec;141(12):1118-27. doi: 10.1001/jamaoto.2015.0764.
4
Detection of HPV-associated oropharyngeal tumours in a 16-year cohort: more than meets the eye.16年队列研究中HPV相关口咽肿瘤的检测：所见不止于此。
Br J Cancer. 2015 Apr 14;112(8):1349-57. doi: 10.1038/bjc.2015.99. Epub 2015 Mar 17.
5
Chemoradiation for advanced oral and (pharyngo) laryngeal carcinoma: single institution outcome analysis.晚期口腔及（咽）喉癌的放化疗：单机构疗效分析
Minerva Stomatol. 2015 Jun;64(3):111-5.
6
Combined TP53 mutation/3p loss correlates with decreased radiosensitivity and increased matrix-metalloproteinase activity in head and neck carcinoma.TP53突变与3p缺失联合出现与头颈部癌放射敏感性降低及基质金属蛋白酶活性增加相关。
Oral Oncol. 2015 May;51(5):470-5. doi: 10.1016/j.oraloncology.2015.01.014. Epub 2015 Feb 27.
7
Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications.头颈部鳞状细胞癌的放射抗性：生物学基础及治疗意义
Head Neck. 2015 May;37(5):763-70. doi: 10.1002/hed.23837. Epub 2015 Jan 27.
8
HPV-related oropharyngeal cancers: from pathogenesis to new therapeutic approaches.人乳头瘤病毒相关的口咽癌：从发病机制到新的治疗方法
Cancer Lett. 2014 Sep 1;351(2):198-205. doi: 10.1016/j.canlet.2014.06.003. Epub 2014 Jun 24.
9
De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma.人乳头瘤病毒相关口咽鳞状细胞癌的降阶梯治疗方案
Cochrane Database Syst Rev. 2014 Feb 15;2014(2):CD010271. doi: 10.1002/14651858.CD010271.pub2.
10
Cyclin D1 overexpression is associated with poor prognosis in oropharyngeal cancer.Cyclin D1 过表达与口咽癌预后不良相关。
J Otolaryngol Head Neck Surg. 2013 Mar 19;42(1):23. doi: 10.1186/1916-0216-42-23.