Hazlett Linda D, McClellan Sharon A, Ekanayaka Sandamali A
Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA.
Department of Ophthalmology, Wayne State University, School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA.
J Rare Dis Res Treat. 2016;1(1):36-39. Epub 2016 Jul 18.
is a Gram negative bacterium widely dispersed in the environment which can cause acute and chronic infections in humans. According to the Centers for Disease Control and Prevention (CDC), the overall incidence of infections in USA hospitals averages about 0.4% (4/1000 discharges), and the bacterium is the fourth most commonly-isolated nosocomial pathogen accounting for 10.1% of all hospital-acquired infections. keratitis is a severe infection of the eye, progresses rapidly and remains a leading cause of corneal ulcers worldwide. Use of contact lenses is the major risk factor in the USA, while in less industrialized countries, trauma from agricultural accidents are of importance. Animal models of bacterial keratitis are of value in the study of this disease and suggest potential alternative therapeutic targets that are needed urgently due to increasing antibiotic resistance. Recently we have shown success and improved disease outcome after down-regulation of one promising target, high mobility group box1 (HMGB1) using small interfering RNA (siRNA). Testing more clinically relevant approaches are underway to reduce HMGB1 levels in keratitis which may hold promise for its treatment.
是一种革兰氏阴性菌,广泛分布于环境中,可导致人类急性和慢性感染。根据美国疾病控制与预防中心(CDC)的数据,美国医院感染的总体发病率平均约为0.4%(每1000例出院患者中有4例),该细菌是第四常见的医院获得性病原体,占所有医院感染的10.1%。细菌性角膜炎是一种严重的眼部感染,进展迅速,仍然是全球角膜溃疡的主要原因。在美国,使用隐形眼镜是主要危险因素,而在工业化程度较低的国家,农业事故造成的创伤则很重要。细菌性角膜炎的动物模型在该疾病的研究中具有价值,并提示了由于抗生素耐药性增加而迫切需要的潜在替代治疗靶点。最近我们已经证明,使用小干扰RNA(siRNA)下调一个有前景的靶点——高迁移率族蛋白B1(HMGB1)后取得了成功并改善了疾病结局。正在测试更多临床相关方法以降低细菌性角膜炎中HMGB1的水平,这可能为其治疗带来希望。