• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

烟酰胺单核苷酸（NMN+）、烟酰胺核糖及其类似物在马肝醇脱氢酶促进的酒精氧化中的活性。NAD+辅酶吡啶核苷酸部分该活性的改善及结构要求。

Activity of NMN+, nicotinamide ribose and analogs in alcohol oxidation promoted by horse-liver alcohol dehydrogenase. Improvement of this activity and structural requirements of the pyridine nucleotide part of the NAD+ coenzyme.

作者信息

Sicsic S, Durand P, Langrené S, Le Goffic F

出版信息

Eur J Biochem. 1986 Mar 3;155(2):403-7. doi: 10.1111/j.1432-1033.1986.tb09505.x.

DOI:10.1111/j.1432-1033.1986.tb09505.x
PMID:2937634
Abstract

Kinetic constants of horse-liver alcohol-dehydrogenase-mediated oxidation of alcohol by nicotinamide mononucleotide and nicotinamide ribose were determined and the role of different adenine moieties complementing the reaction mixtures was investigated. Five nicotinamide ribose analogs were synthesized and their activities as NAD+ inhibitors and as cofactors in this dehydrogenase-mediated oxidation of alcohol were assayed. In the light of these results, structural requirements of the pyridine ribofuranosyl part of the NAD+ are discussed.

摘要

测定了马肝醇脱氢酶介导的烟酰胺单核苷酸和烟酰胺核糖对醇的氧化反应的动力学常数，并研究了反应混合物中不同腺嘌呤部分的作用。合成了5种烟酰胺核糖类似物，并测定了它们作为NAD+抑制剂以及在该脱氢酶介导的醇氧化反应中作为辅因子的活性。根据这些结果，讨论了NAD+中吡啶核糖呋喃糖部分的结构要求。

相似文献

1
Activity of NMN+, nicotinamide ribose and analogs in alcohol oxidation promoted by horse-liver alcohol dehydrogenase. Improvement of this activity and structural requirements of the pyridine nucleotide part of the NAD+ coenzyme.烟酰胺单核苷酸（NMN+）、烟酰胺核糖及其类似物在马肝醇脱氢酶促进的酒精氧化中的活性。NAD+辅酶吡啶核苷酸部分该活性的改善及结构要求。
Eur J Biochem. 1986 Mar 3;155(2):403-7. doi: 10.1111/j.1432-1033.1986.tb09505.x.
2
Alteration in substrate specificity of horse liver alcohol dehydrogenase by an acyclic nicotinamide analog of NAD(+).NAD⁺的无环烟酰胺类似物对马肝醇脱氢酶底物特异性的改变
DNA Repair (Amst). 2014 Nov;23:95-100. doi: 10.1016/j.dnarep.2014.09.005. Epub 2014 Oct 3.
3
Synthesis and properties of new coenzyme mimics based on the artificial coenzyme CL4.基于人工辅酶CL4的新型辅酶模拟物的合成与性质
J Mol Recognit. 1999 Jan-Feb;12(1):45-56. doi: 10.1002/(SICI)1099-1352(199901/02)12:1<45::AID-JMR374>3.0.CO;2-9.
4
Crystallographic investigations of nicotinamide adenine dinucleotide binding to horse liver alcohol dehydrogenase.烟酰胺腺嘌呤二核苷酸与马肝醇脱氢酶结合的晶体学研究。
Biochemistry. 1984 Dec 4;23(25):5982-96. doi: 10.1021/bi00320a014.
5
THE ACTIVITY OF LIVER ALCOHOL DEHYDROGENASE WITH NICOTINAMIDE-ADENINE DINUCLEOTIDE PHOSPHATE AS COENZYME.以烟酰胺腺嘌呤二核苷酸磷酸为辅酶的肝脏乙醇脱氢酶活性
Biochem J. 1965 May;95(2):311-20. doi: 10.1042/bj0950311.
6
HUMAN LIVER--ALCOHOL DEHYDROGENASE. KINETIC AND PHYSICOCHEMICAL PROPERTIES.人类肝脏——乙醇脱氢酶。动力学和物理化学性质。
Biochemistry. 1964 Nov;3:1775-82. doi: 10.1021/bi00899a033.
7
A new approach for using cofactor dependent enzymes: example of alcohol dehydrogenase.一种使用辅因子依赖性酶的新方法：以乙醇脱氢酶为例。
FEBS Lett. 1984 Oct 29;176(2):321-30. doi: 10.1016/0014-5793(84)81188-6.
8
Investigation of the nature of enzyme--coenzyme interactions in binary and ternary complexes of liver alcohol dehydrogenase with coenzymes, coenzyme analogues, and substrate analogues by ultraviolet absorption and phosphorescence spectroscopy.通过紫外吸收光谱和磷光光谱研究肝脏乙醇脱氢酶与辅酶、辅酶类似物和底物类似物的二元及三元复合物中酶 - 辅酶相互作用的性质。
Biochemistry. 1981 Jul 7;20(14):4086-93. doi: 10.1021/bi00517a022.
9
The interaction of liver alcohol dehydrogenase with phenyl adenine dinucleotide, a novel analog of pyridine nucleotide coenzymes.肝脏乙醇脱氢酶与苯基腺嘌呤二核苷酸（一种新型吡啶核苷酸辅酶类似物）的相互作用。
J Biol Chem. 1978 Sep 10;253(17):5886-7.
10
Dependence of the substrate specificity and kinetic mechanism of horse-liver alcohol dehydrogenase on the size of the C-3 pyridinium substituent. 3-Benzoylpyridine-adenine dinucleotide.马肝醇脱氢酶的底物特异性和动力学机制对C-3吡啶鎓取代基大小的依赖性。3-苯甲酰基吡啶-腺嘌呤二核苷酸。
Eur J Biochem. 1986 Sep 1;159(2):375-80. doi: 10.1111/j.1432-1033.1986.tb09878.x.

引用本文的文献

1
A High-Throughput Method for Directed Evolution of NAD(P)-Dependent Dehydrogenases for the Reduction of Biomimetic Nicotinamide Analogues.一种用于NAD(P)依赖性脱氢酶定向进化以还原仿生烟酰胺类似物的高通量方法。
ACS Catal. 2019 Dec 6;9(12):11709-11719. doi: 10.1021/acscatal.9b03840. Epub 2019 Nov 7.
2
Engineering natural and noncanonical nicotinamide cofactor-dependent enzymes: design principles and technology development.工程化天然和非规范烟酰胺辅酶依赖酶：设计原则和技术开发。
Curr Opin Biotechnol. 2020 Dec;66:217-226. doi: 10.1016/j.copbio.2020.08.005. Epub 2020 Sep 18.