接受人绝经促性腺激素治疗、枸橼酸氯米芬治疗及未治疗的妊娠周期中的不同激素模式。

Different hormonal patterns in human menopausal gonadotropin-treated, clomiphene citrate-treated, and untreated conception cycles.

作者信息

Bohnet H G, Kato K, Trapp M, Weise H C, Leidenberger F A

出版信息

Fertil Steril. 1986 Apr;45(4):469-74. doi: 10.1016/s0015-0282(16)49271-x.

Abstract

Serum concentrations of seven different hormones were analyzed during 189 singleton conception cycles. One hundred nine women were treated with human menopausal gonadotropin (hMG), 52 women received clomiphene citrate (CC), and 28 became pregnant spontaneously. Serum progesterone (P) levels in hMG-treated women started to increase on day 18 of the cycle and reached peak concentrations between days 28 and 32 of the cycle. Serum estradiol (E2) concentrations paralleled the P patterns. In hMG-treated women, there were significant correlations between serum E2 and P concentrations and the number of the mature follicles observed before ovulation (both P less than 0.01). CC-treated and spontaneous conception cycles revealed significantly lower serum levels of P, E2, testosterone, 17 alpha-hydroxyprogesterone, and prolactin, compared with hMG-treated cycles (P less than 0.05). Elevations of the gonadal steroids in hMG-treated women possibly reflect the multiple corpora lutea formed after multiple ovulations.

摘要

在189个单胎妊娠周期中分析了七种不同激素的血清浓度。109名女性接受了人绝经期促性腺激素（hMG）治疗，52名女性接受了枸橼酸氯米芬（CC）治疗，28名女性自然受孕。hMG治疗的女性血清孕酮（P）水平在周期第18天开始升高，并在周期第28天至32天之间达到峰值浓度。血清雌二醇（E2）浓度与P的变化模式相似。在hMG治疗的女性中，血清E2和P浓度与排卵前观察到的成熟卵泡数量之间存在显著相关性（均P<0.01）。与hMG治疗的周期相比，CC治疗和自然受孕周期的血清P、E2、睾酮、17α-羟孕酮和催乳素水平显著降低（P<0.05）。hMG治疗的女性性腺类固醇升高可能反映了多次排卵后形成的多个黄体。