Ataş Erman, Koç Ozan, Artık Hatice A
Department of Pediatric Oncology, Universitiy of Health Sciences, Gülhane Training and Research Hospital, Pediatrics, Ankara, Turkey.
Department of Pediatrics, Universitiy of Health Sciences, Gülhane Training and Research Hospital, Pediatrics, Ankara, Turkey.
Turk J Pediatr. 2017;59(3):254-260. doi: 10.24953/turkjped.2017.03.004.
Ataş E, Koç O, Artık HA. Clinical features and treatment results in children with hemangioma. Turk J Pediatr 2017; 59: 254-260. Hemangioma is a frequent disease which has a proliferative and involution phase. In this single center retrospective study, we evaluated clinical and therapeutic features of hemangiomas in children (n: 49). The median (range) age at onset and at admission were 21 days (10 days-156 months) and 7 months (0.25-192 months), respectively. The localization of lesions was: head region (n: 28; 57.2%), trunk (n: 8; 16.3%) trunk, limb (n: 8; 16.3%), and neck region (n: 5; 10.2%) neck region. Seventeen patients (34.7%) were treated. Following treatments were used: propranolol alone in 12 (24.5%) patients, steroid alone in 2 (4.1%) patients, prednisone plus propranolol in 2 (4.1%) patients, and propranolol plus surgery in 1 (2.0%) patient. The number of hemangioma (n > 1) (p = 0.026, OR = 9.5, 95% CI 1.3-69.2) and treatment other than observation (p = 0.008, OR = 10.5, 95% CI 1.8-59.1) were significant predictors in the univariate analysis; treatment other than observation was an independent predictor for clinical response (p = 0.014, OR = 9.8, 95% CI 1.5-90.9).
阿塔什·E、科克·O、阿尔蒂克·H·A。血管瘤患儿的临床特征及治疗结果。《土耳其儿科学杂志》2017年；59: 254 - 260。血管瘤是一种常见疾病，有增殖期和消退期。在这项单中心回顾性研究中，我们评估了49例儿童血管瘤的临床和治疗特征。发病时和入院时的中位（范围）年龄分别为21天（10天 - 156个月）和7个月（0.25 - 192个月）。病变部位为：头部区域（28例；57.2%）、躯干（8例；16.3%）、四肢（8例；16.3%）和颈部区域（5例；10.2%）。17例患者（34.7%）接受了治疗。采用的治疗方法如下：12例（24.5%）患者单独使用普萘洛尔，2例（4.1%）患者单独使用类固醇，2例（4.1%）患者使用泼尼松加普萘洛尔，1例（2.0%）患者使用普萘洛尔加手术。单因素分析中，血管瘤数量（n > 1）（p = 0.026，OR = 9.5，95% CI 1.3 - 69.2）和非观察性治疗（p = 0.008，OR = 10.5，95% CI 1.8 - 59.1）是显著预测因素；非观察性治疗是临床反应的独立预测因素（p = 0.014，OR = 9.8，95% CI 1.5 - 90.9）。
