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[移植物抗宿主反应的T效应细胞诱导过程中巨噬细胞与胸腺细胞相互作用的主要组织相容性复合体基因控制。I. 细胞水平的遗传控制]

[Control by major histocompatibility complex genes of macrophage interaction with thymocytes during induction of T-effectors of graft vs host reaction. I. Genetic control on the cellular level].

作者信息

Galaktionov V G, Anfalova T V, Lutsan N I, Golenishchev V Iu, Poznakhirev P R

出版信息

Genetika. 1986 Feb;22(2):244-52.

PMID:2937686
Abstract

H-2 complex control of interaction between macrophages and thymocytes during induction of T-cell effectors GVH was studied. Intensity of the local GVH reaction was evaluated by the index of the lymph nodes enlargement. Genes of the H-2 system control interaction of macrophages with thymocytes during the formation of T-cell effectors GVH. H-2K subregion genes identity of interacting cells was necessary and sufficient for the effective induction of T-effectors GVH. I and D region differences did not affect the formation of T-cells inducing GVH.

摘要

研究了H-2复合体在T细胞效应物GVH诱导过程中对巨噬细胞与胸腺细胞相互作用的控制。通过淋巴结肿大指数评估局部GVH反应的强度。H-2系统的基因在T细胞效应物GVH形成过程中控制巨噬细胞与胸腺细胞的相互作用。相互作用细胞的H-2K亚区基因相同对于有效诱导GVH的T效应物是必要且充分的。I区和D区的差异不影响诱导GVH的T细胞的形成。

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