WestCHEM, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, Glasgow, UK.
WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK.
J Biophotonics. 2018 Apr;11(4):e201700299. doi: 10.1002/jbio.201700299. Epub 2018 Mar 5.
The complex patterns observed from evaporated liquid drops have been examined extensively over the last 20 years. Complete understanding of drop deposition is vital in many medical processes, and one which is essential to the translation of biofluid spectroscopic disease diagnostics. The promising use of spectroscopy in disease diagnosis has been hindered by the complicated patterns left by dried biological fluids which may inhibit the clinical translation of this technology. Coffee-ring formation, cracking and gelation patterns have all been observed in biofluid drops, and with surface homogeneity being a key element to many spectroscopic techniques, experimental issues have been found to arise. A better understanding of the fundamental processes involved in a drying droplet could allow efficient progression in this research field, and ultimately benefit the population with the development of a reliable cancer diagnostic.
在过去的 20 年中，人们对蒸发液滴中观察到的复杂模式进行了广泛的研究。在许多医疗过程中，完全理解液滴沉积是至关重要的，这对于将生物流体光谱疾病诊断转化为临床应用也很重要。光谱学在疾病诊断中的应用前景受到阻碍，因为干燥的生物流体留下的复杂模式可能会抑制该技术的临床应用。在生物流体液滴中已经观察到咖啡环形成、开裂和胶凝模式，而由于表面均一性是许多光谱技术的关键要素，因此已经发现实验中会出现问题。对干燥液滴中涉及的基本过程有更好的了解，可以促进该研究领域的快速发展，并最终通过开发可靠的癌症诊断方法使公众受益。
