Enríquez-Marulanda Alejandro, Beltrán-Osorio Luis David, Escobar Luis Alberto, Granados Ana María, Velásquez-Lasprilla Fernando, Orozco Jorge Luis
Universidad Icesi, Faculty of Medicine, Cali, Colombia; Clinical Research Centre, Cali, Colombia; Department of Neuroscience, Fundación Valle del Lili Hospital, Cali, Colombia.
Clinical Research Centre, Cali, Colombia; Department of Neuroscience, Fundación Valle del Lili Hospital, Cali, Colombia.
World Neurosurg. 2018 Apr;112:117-122. doi: 10.1016/j.wneu.2018.01.105. Epub 2018 Feb 10.
Paraneoplastic cerebellar degeneration (PCD) is a rare complication of some malignant cancers. It is most commonly described in women with gynecologic or breast malignancies; however, there have been reports in other types of cancers. Symptoms include ataxia, dysarthria, and tremors, which could be the first manifestations of an underlying malignancy.
A 50-year-old woman had an acute PCD with anti-Yo antibodies from an underlying breast invasive ductal carcinoma. She presented with intracranial hypertension in the posterior cranial fossa that required an emergent decompressive craniectomy.
PCD is an uncommon disease that may manifest initially as posterior cranial fossa hypertension and subsequent acute hydrocephalus owing to diffuse cerebellar swelling. To our knowledge, this is the first described case of an anti-Yo PCD that has manifested as acute posterior cranial fossa hypertension owing to diffuse cerebellar edema. Early diagnosis and treatment should be pursued to improve long-term outcomes.
副肿瘤性小脑变性（PCD）是某些恶性肿瘤的罕见并发症。它最常见于患有妇科或乳腺恶性肿瘤的女性；然而，其他类型癌症也有相关报道。症状包括共济失调、构音障碍和震颤，这些可能是潜在恶性肿瘤的首发表现。
一名50岁女性因潜在的乳腺浸润性导管癌出现伴有抗Yo抗体的急性PCD。她表现为后颅窝颅内高压，需要紧急进行减压颅骨切除术。
PCD是一种罕见疾病，最初可能表现为后颅窝高压及随后因弥漫性小脑肿胀导致的急性脑积水。据我们所知，这是首例因弥漫性小脑水肿表现为急性后颅窝高压的抗Yo PCD病例。应尽早诊断和治疗以改善长期预后。
