Sains P, Chana K S, Sridhar V, Sajid M S
Department of General, Endoscopic and Laparoscopic Colorectal Surgery, Brighton & Sussex University Hospital NHS Trust, Eastern Rd, Brighton, East Sussex, BN2 5BE, UK.
Osney Thermo-fluids Laboratory, Department of Engineering Science, University of Oxford, Oxford, OX1 3PJ, UK.
BMC Res Notes. 2018 Jan 29;11(1):81. doi: 10.1186/s13104-018-3163-6.
The objective of this article is to briefly outline the utilization of biosensors in medicine and surgery and present diagnostic efficacy of thermal product (TP) based biosensor.
The working principle of biosensor is based on measuring TP of a material in contact with the sensor. When an electrical square wave pulse of certain amplitude and duration is passed through TP based biosensor, the generated heat from its higher resistance will be dissipated and recorded by the sensor. As the surrounding material composition changes, the dissipated heat split between the sensor substrate and surrounding material changes which can be correlated to the change in TP of the material. For biological tissues, it is known that the thermal properties of tissues are quite different for different layers in the body and hence the heat absorbed will be different. The experiments were conducted on biological and non-biological tissues. For data acquisition software LabView 2014 (64-bit) was used and software used for post-processing was MATLAB R2015a (64-bit). The resulting graphs of TP from various materials (oil, water, saline, acetone) and biological tissue (porcine belly, porcine thigh layers and porcine abdominal viscera) expressed prominent deflections indicating diagnostic efficacy of TP based biosensor.
本文的目的是简要概述生物传感器在医学和外科手术中的应用，并介绍基于热产物（TP）的生物传感器的诊断效能。
生物传感器的工作原理基于测量与传感器接触的材料的TP。当一定幅度和持续时间的电方波脉冲通过基于TP的生物传感器时，其较高电阻产生的热量将被耗散并由传感器记录。随着周围材料成分的变化，在传感器基板和周围材料之间分配的耗散热量也会改变，这可以与材料TP的变化相关联。对于生物组织，已知身体不同层的组织热特性有很大差异，因此吸收的热量也会不同。对生物和非生物组织进行了实验。数据采集使用软件LabView 2014（64位），后处理使用软件MATLAB R2015a（64位）。来自各种材料（油、水、盐水、丙酮）和生物组织（猪腹部、猪大腿层和猪腹部内脏）的TP结果图显示出明显的偏差，表明基于TP的生物传感器具有诊断效能。
