Strauer B E, Bayer F, Brecht H M, Motz W
J Hypertens Suppl. 1985 Dec;3(4):S39-44.
Pharmacotherapeutical means of reversing cardiac hypertrophy (prazosin, clonidine and nifedipine) were analysed in concentrically, as well as eccentrically, hypertrophied left ventricles. Regression of cardiac hypertrophy, i.e. a therapeutic intervention on a critical precursor of hypertensive congestive heart failure, can be obtained by various antihypertensive agents. Prazosin, calcium channel blockers, clonidine and angiotensin converting enzyme inhibitors as well as a combined treatment regimen using alpha-receptor blockers together with diuretics and vasodilators can all induce regression of hypertrophy associated with an improvement in left ventricular function. Moreover, an improved coronary reserve may reduce the ischaemic risk of the hypertrophied myocardium. However, not all antihypertensive drugs seem equally effective in bringing about coronary regression of left ventricular hypertrophy (LVH). No regression or little regression has been found with diuretic monotherapy despite a satisfactory reduction in blood pressure. On the other hand, a trend towards a regression has been observed in patients in whom treatment with clonidine significantly reduced catecholamines.
在向心性肥厚以及离心性肥厚的左心室中，对逆转心脏肥大的药物治疗方法（哌唑嗪、可乐定和硝苯地平）进行了分析。心脏肥大的消退，即对高血压性充血性心力衰竭的关键前驱因素进行的治疗干预，可以通过多种抗高血压药物实现。哌唑嗪、钙通道阻滞剂、可乐定和血管紧张素转换酶抑制剂，以及使用α受体阻滞剂联合利尿剂和血管扩张剂的联合治疗方案，都可以诱导与左心室功能改善相关的肥大消退。此外，改善的冠状动脉储备可能会降低肥厚心肌的缺血风险。然而，并非所有抗高血压药物在导致左心室肥厚（LVH）的冠状动脉消退方面似乎都同样有效。尽管血压得到了令人满意的降低，但利尿剂单一疗法未发现消退或仅有轻微消退。另一方面，在可乐定治疗显著降低儿茶酚胺的患者中观察到了消退的趋势。
