Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Am J Cardiol. 2010 Jul 1;106(1):110-6. doi: 10.1016/j.amjcard.2010.02.022. Epub 2010 May 13.
The effect of cardiovascular risk factors on the left ventricle is well known but their effect on right ventricle has not been studied using advanced imaging techniques. The purpose of the present study was to determine the relation between the cardiovascular risk factors and right ventricular (RV) structure and function and its interaction with the left ventricle. Cardiac magnetic resonance images from 4,204 participants free of clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis were analyzed. Multivariate linear regression models were used to study the cross-sectional association between individual RV parameters and risk factors. All RV parameters, except for ejection fraction, decreased with age (p <0.0001). The RV mass was positively associated with systolic blood pressure (+0.4 g, p <0.0001) and high-density lipoprotein cholesterol (+0.2 g, p <0.0001). It was inversely related with diastolic blood pressure (-0.3 g, p <0.0001) and total cholesterol (-0.2 g, p <0.01). The RV end-diastolic volume was positively associated with systolic blood pressure (+1.6 ml, p <0.01) and high-density lipoprotein cholesterol (+1.8 ml, p <0.0001). It was inversely related with diastolic blood pressure (-2.2 ml, p <0.01), total cholesterol (-1.4 ml, p <0.0001), current smoking (-2.7 ml, p <0.05), and diabetes mellitus (-3.1 ml, p <0.01). The RV ejection fraction was positively associated with systolic blood pressure (+1.0%, p <0.0001), high-density lipoprotein cholesterol (+0.4%, p <0.0001) and inversely with diastolic blood pressure (-0.7%, p <0.0001). In conclusion, the mass and volumes of the right ventricle decrease with age. Cardiovascular risk factors, especially blood pressure and high-density lipoprotein cholesterol, are associated with subclinical changes in the RV mass and volume.
心血管危险因素对左心室的影响众所周知，但它们对右心室的影响尚未通过先进的成像技术进行研究。本研究的目的是确定心血管危险因素与右心室（RV）结构和功能之间的关系及其与左心室的相互作用。在无临床心血管疾病的多民族动脉粥样硬化研究中，对 4204 名参与者的心脏磁共振图像进行了分析。使用多元线性回归模型研究了个体 RV 参数与危险因素的横断面相关性。除射血分数外，所有 RV 参数均随年龄增加而降低（p<0.0001）。RV 质量与收缩压呈正相关（+0.4g，p<0.0001），与高密度脂蛋白胆固醇呈正相关（+0.2g，p<0.0001）。与舒张压呈负相关（-0.3g，p<0.0001），与总胆固醇呈负相关（-0.2g，p<0.01）。RV 舒张末期容积与收缩压呈正相关（+1.6ml，p<0.01），与高密度脂蛋白胆固醇呈正相关（+1.8ml，p<0.0001）。与舒张压呈负相关（-2.2ml，p<0.01），与总胆固醇呈负相关（-1.4ml，p<0.0001），与当前吸烟呈负相关（-2.7ml，p<0.05），与糖尿病呈负相关（-3.1ml，p<0.01）。RV 射血分数与收缩压呈正相关（+1.0%，p<0.0001），与高密度脂蛋白胆固醇呈正相关（+0.4%，p<0.0001），与舒张压呈负相关（-0.7%，p<0.0001）。总之，右心室的质量和容积随年龄而降低。心血管危险因素，尤其是血压和高密度脂蛋白胆固醇，与 RV 质量和容积的亚临床变化有关。
