Roumeguère Thierry, Legrand Francois, Rassy Elie El, Kaitouni Mehdi Idrissi, Albisinni Simone, Rousseau Alexandre, Vanhaeverbeek Michel, Rorive Sandrine, Decaestecker Christine, Debeir Olivier, Boudjeltia Karim Zouaoui, Aoun Fouad
Department of Urology, University Clinics of Brussels, Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Laboratory of Experimental Medicine, Unit 222 ULB, Hôpital André Vésale, CHU Charleroi, Montigny-le-Tilleuil, Belgium.
Future Sci OA. 2017 Nov 15;4(2):FSO266. doi: 10.4155/fsoa-2017-0084. eCollection 2018 Feb.
We evaluated the relationship between IL-8 and prostate cancer (PCa) with emphasis on diagnosis, aggressiveness and prognosis.
MATERIALS & METHODS: Prostate-specific antigen (PSA) and serum IL-8 were collected from patients undergoing prostate biopsy. IL-8 expression was evaluated on immunohistochemistry with IL-8 labeling index. Complete follow-up of this cohort was achieved over a period of up to 6 years with continuous follow-up of PSA levels.
Among 135 patients, serum IL-8 level did not correlate to the diagnosis or aggressiveness of PCa. In 52 radical prostatectomy specimens, a higher IL-8 labeling index was detected in the tumor areas (0.4 ± 0.2 vs 0.33 ± 0.2; p = 0,007) but did not correlate to any of the prognostic markers: D'Amico classification (p = 0.52), Gleason score (p = 0.45), perineural (p = 0.83) and capsular invasion (p = 0.75). No correlation was found to PSA biochemical-free failure.
IL-8 serum level was not a significant predictor of diagnosis, aggressiveness or prognosis of PCa.
我们评估了白细胞介素-8（IL-8）与前列腺癌（PCa）之间的关系，重点关注诊断、侵袭性和预后。
收集接受前列腺活检患者的前列腺特异性抗原（PSA）和血清IL-8。通过IL-8标记指数对IL-8表达进行免疫组织化学评估。对该队列进行了长达6年的完整随访，并持续监测PSA水平。
在135例患者中，血清IL-8水平与PCa的诊断或侵袭性无关。在52例根治性前列腺切除术标本中，肿瘤区域检测到较高的IL-8标记指数（0.4±0.2对0.33±0.2；p=0.007），但与任何预后标志物均无相关性：D’Amico分级（p=0.52）、Gleason评分（p=0.45）、神经周围侵犯（p=0.83）和包膜侵犯（p=0.75）。与PSA无生化复发也无相关性。
IL-8血清水平不是PCa诊断、侵袭性或预后的重要预测指标。
