Department of Emergency Medicine, Nantou Hospital, Nantou, Taiwan.
Br J Cancer. 2013 May 14;108(9):1778-83. doi: 10.1038/bjc.2013.184. Epub 2013 Apr 23.
The incidence of prostate cancer is much lower in Asian men than in Western men. This study investigated whether prostate cancer is associated with prostatitis, benign prostatic hyperplasia (BPH), and other medical conditions in the low-incidence population.
From the claims data obtained from the universal National Health Insurance of Taiwan, we identified 1184 patients with prostate cancer diagnosed from 1997 to 2008. Controls comprised 4736 men randomly selected from a cancer-free population. Both groups were 50 years of age or above. Medical histories between the two groups were compared.
Multivariate logistic regression analysis showed that prostatitis and BPH had stronger association with prostate cancer than the other medical conditions tested. Compared with men without prostatitis and BPH, a higher odds ratio (OR) for prostate cancer was associated with BPH (26.2, 95% confidence interval (CI) 20.8-33.0) than with prostatitis (10.5, 95% CI=3.36-32.7). Men with both conditions had an OR of 49.2 (95% CI=34.7-69.9).
Men with prostate cancer have strong association with prostatitis and/or BPH. Prostatitis interacts with BPH, resulting in higher estimated relative risk of prostate cancer in men suffering from both conditions.
亚洲男性的前列腺癌发病率远低于西方男性。本研究旨在探讨在低发人群中，前列腺癌是否与前列腺炎、良性前列腺增生（BPH）和其他医疗状况相关。
我们从台湾全民健康保险的理赔数据中，确定了 1997 年至 2008 年间诊断出的 1184 名前列腺癌患者。对照组由从无癌症人群中随机抽取的 4736 名男性组成。两组年龄均在 50 岁以上。比较两组之间的病史。
多变量逻辑回归分析显示，前列腺炎和 BPH 与前列腺癌的相关性强于其他测试的医疗状况。与无前列腺炎和 BPH 的男性相比，BPH（26.2，95%置信区间[CI]20.8-33.0）与前列腺癌的比值比（OR）高于前列腺炎（10.5，95%CI=3.36-32.7）。同时患有这两种疾病的男性的 OR 为 49.2（95%CI=34.7-69.9）。
患有前列腺癌的男性与前列腺炎和/或 BPH 有很强的相关性。前列腺炎与 BPH 相互作用，导致同时患有这两种疾病的男性前列腺癌的相对风险估计值更高。
