Altmäe Signe, Mendoza-Tesarik Raquel, Mendoza Carmen, Mendoza Nicolas, Cucinelli Francesco, Tesarik Jan
Competence Centre on Health Technologies, University of Tartu, 50410 Tartu, Estonia.
Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, 18016 Granada, Spain.
J Endocr Soc. 2017 Dec 19;2(1):96-105. doi: 10.1210/js.2017-00359. eCollection 2018 Jan 1.
Administration of growth hormone (GH) during ovarian stimulation has been shown to improve success rates of fertilization. GH beneficial effect on oocyte quality is shown in several studies, but GH effect on uterine receptivity is not clear. To assess it, we studied whether GH administration can improve the chance of pregnancy and birth in women who experienced repeated implantation failure (RIF) using donated oocyte programs.
A total of 105 infertile women were enrolled in the randomized controlled trial: 70 women were with a history of RIF with donated oocytes, and 35 infertile women underwent the first oocyte donation attempt. Women receiving donated oocytes were treated with progressively increasing doses of oral estradiol, followed by intravaginal progesterone after previous pituitary desensitization with gonadotropin-releasing hormone agonist. Thirty-five RIF patients were treated with GH (GH patients), whereas the rest of the 35 RIF patients (non-GH patients) and 35 first-attempt patients (positive control group) were not.
RIF patients receiving GH showed significantly thicker endometrium and higher pregnancy and live birth rates as compared with RIF patients of non-GH study group, although these rates remained somewhat lower as compared with the non-RIF patients of the positive control group. No abnormality was detected in any of the babies born.
Our data of improved implantation, pregnancy, and live birth rates among infertile RIF patients treated with GH indicate that GH improves uterine receptivity.
在卵巢刺激过程中使用生长激素（GH）已被证明可提高受精成功率。多项研究表明GH对卵母细胞质量有有益影响，但GH对子宫容受性的影响尚不清楚。为评估这一点，我们研究了在使用捐赠卵母细胞方案的反复种植失败（RIF）女性中，给予GH是否能提高怀孕和分娩几率。
共有105名不孕女性参与了这项随机对照试验：70名女性有捐赠卵母细胞的RIF病史，35名不孕女性首次尝试接受卵母细胞捐赠。接受捐赠卵母细胞的女性先用逐渐增加剂量的口服雌二醇治疗，然后在先前用促性腺激素释放激素激动剂使垂体脱敏后给予阴道内孕酮。35名RIF患者接受GH治疗（GH组患者），而其余35名RIF患者（非GH组患者）和35名首次尝试患者（阳性对照组）未接受GH治疗。
与非GH研究组的RIF患者相比，接受GH治疗的RIF患者子宫内膜明显更厚，怀孕和活产率更高，尽管与阳性对照组的非RIF患者相比，这些比率仍略低。出生的婴儿均未检测到异常。
我们的数据表明，在接受GH治疗的不孕RIF患者中，着床、怀孕和活产率有所提高，这表明GH可改善子宫容受性。
