Autret A, Saudeau D
Presse Med. 1986 Feb 8;15(5):205-9.
Atheroma of the carotid bifurcation can be held responsible for 15% of the 150 000 cases of cerebrovascular attack recorded annually in France. Most of these are caused by an embolus detached from the thrombus formed around the atheromatous lesions. The natural history of asymptomatic carotid stenosis is imperfectly known because the patients are very heterogeneous. However, published series suggest that the risk of ischaemic complication in cases with more than 50% stenosis is about 0.7% per annum. No medical treatment has been tested against this disease. On the other hand, several uncontrolled studies have highlighted the therapeutic value of endarterectomy. The tendency towards surgery may become more widespread as non-invasive detection by ultrasounds is increasingly used. A randomized therapeutic trial is required to determine the value of this operation and the maximum tolerable morbidity rate. In the case of transient ischaemic attacks, a joint study on extracranial arterial occlusion has demonstrated the value of successful endarterectomy and shown that the maximum tolerable morbidity from surgery is 3%. Slightly higher figures are probably acceptable for cases with tight stenosis. Such an approach cannot determine whether endarterectomy would be of value in completed stroke, because the pathological conditions involved are extremely variable. Reasoning by analogy with transient ischaemic attacks, it would seem that tight or ulcerated stenoses could benefit from the operation some time after a regressive stroke. Ultrasonic techniques and intravenous angiography have made examination of the cervical arteries considerably easier. The risk of wounding the left carotid artery should be carefully weighed. Preoperative cardiac assessment is necessary in view of the high incidence of heart disease in the follow-up of these patients. Thus, natural history data set high standards for surgical performance and less risk for pre-operative investigations.
在法国,每年记录的15万例脑血管疾病发作病例中,15%可归因于颈动脉分叉处的动脉粥样硬化。其中大多数是由动脉粥样硬化病变周围形成的血栓脱落的栓子引起的。无症状性颈动脉狭窄的自然病史尚不完全清楚,因为患者差异很大。然而,已发表的系列研究表明,狭窄超过50%的患者每年发生缺血性并发症的风险约为0.7%。目前尚无针对该疾病的药物治疗经过验证。另一方面,一些非对照研究强调了动脉内膜切除术的治疗价值。随着超声无创检测的日益普及,手术治疗的趋势可能会更加广泛。需要进行一项随机治疗试验来确定该手术的价值以及最大可耐受的发病率。在短暂性脑缺血发作的情况下,一项关于颅外动脉闭塞的联合研究证明了成功的动脉内膜切除术的价值,并表明手术的最大可耐受发病率为3%。对于严重狭窄的病例,略高的数字可能也是可以接受的。这样的方法无法确定动脉内膜切除术在完全性卒中中是否有价值,因为所涉及的病理状况极为多样。通过与短暂性脑缺血发作进行类比推理,似乎严重或溃疡性狭窄在卒中病情好转一段时间后可能会从手术中获益。超声技术和静脉血管造影使颈动脉检查变得容易得多。应仔细权衡损伤左颈动脉的风险。鉴于这些患者随访中心脏病的高发病率,术前心脏评估是必要的。因此,自然病史数据为手术操作设定了高标准,术前检查的风险也更低。