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评价细胞穿透肽包覆的 Mn:ZnS 纳米颗粒用于紫杉醇向癌细胞的递送。

Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells.

机构信息

Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.

Department of Brain and Bioengineering, Institute of Health Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.

出版信息

Sci Rep. 2018 Jan 30;8(1):1899. doi: 10.1038/s41598-018-20255-x.

DOI:10.1038/s41598-018-20255-x
PMID:29382898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5789852/
Abstract

This work aimed at formulating paclitaxel (PTX) loaded cell penetrating peptide (CPP) coated Mn doped ZnS nanoparticles (Mn:ZnS NPs) for improved anti-cancer efficacy in vitro and in vivo. The developed PTX loaded Mn:ZnS NPs with different CPPs (PEN, pVEC and R9) showed enhanced anti-cancer effect compared to bare PTX, which has been validated by MTT assay followed by apoptosis assay and DNA fragmentation analysis. The in vivo bio-distribution and anti-cancer efficacy was studied on breast cancer xenograft model showing maximum tumor localization and enhanced therapeutic efficacy with R9 coated Mn:ZnS NPs (R9:Mn:ZnS NPs) and was confirmed by H/E staining. Thus, R9:Mn:ZnS NPs could be an ideal theranostic nano-carrier for PTX with enhanced  the rapeutic efficacy toward cancer cells, where penetration and sustainability of therapeutics are essential.

摘要

本工作旨在制备载紫杉醇（PTX）的细胞穿透肽（CPP）包覆的锰掺杂硫化锌纳米粒子（Mn:ZnS NPs），以提高其在体外和体内的抗癌疗效。与裸 PTX 相比，用不同 CPP（PEN、pVEC 和 R9）制备的载 PTX 的 Mn:ZnS NPs 显示出增强的抗癌效果，这已通过 MTT 测定、随后的细胞凋亡测定和 DNA 片段化分析得到验证。在乳腺癌异种移植模型中研究了体内生物分布和抗癌疗效，结果表明，用 R9 包覆的 Mn:ZnS NPs（R9:Mn:ZnS NPs）具有最大的肿瘤定位和增强的治疗效果，并通过 H/E 染色得到证实。因此，R9:Mn:ZnS NPs 可以作为 PTX 的理想治疗性纳米载体，增强对癌细胞的治疗效果，其中治疗药物的穿透性和持续性至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/87331671dd75/41598_2018_20255_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/4bf6eeaa3b66/41598_2018_20255_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/c17500ef36d1/41598_2018_20255_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/e4a740be0080/41598_2018_20255_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/268f1a469ff8/41598_2018_20255_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/156f56dac906/41598_2018_20255_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/2c1edfcf81f6/41598_2018_20255_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/87331671dd75/41598_2018_20255_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/4bf6eeaa3b66/41598_2018_20255_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/c17500ef36d1/41598_2018_20255_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/e4a740be0080/41598_2018_20255_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/268f1a469ff8/41598_2018_20255_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/156f56dac906/41598_2018_20255_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/2c1edfcf81f6/41598_2018_20255_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc69/5789852/87331671dd75/41598_2018_20255_Fig7_HTML.jpg

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Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells.

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引用本文的文献

[1]
Investigation of the Interaction between Mechanosynthesized ZnS Nanoparticles and Albumin Using Fluorescence Spectroscopy.

Pharmaceuticals (Basel). 2023-8-29

[2]
The role of cell-penetrating peptides in potential anti-cancer therapy.

Clin Transl Med. 2022-5

[3]
Imaging modification of colon carcinoma cells exposed to lipid based nanovectors for drug delivery: a scanning electron microscopy investigation.

RSC Adv. 2019-7-15

本文引用的文献

[1]
Protease-activatable cell-penetrating peptide possessing ROS-triggered phase transition for enhanced cancer therapy.

J Control Release. 2017-8-24

[2]
Targeted drug delivery of Sunitinib Malate to tumor blood vessels by cRGD-chiotosan-gold nanoparticles.

Int J Pharm. 2017-1-30

[3]
Fluorescence and drug loading properties of ZnSe:Mn/ZnS-Paclitaxel/SiO nanocapsules templated by F127 micelles.

J Colloid Interface Sci. 2017-3-15

[4]
Superparamagnetic iron oxide nanoparticles conjugated with folic acid for dual target-specific drug delivery and MRI in cancer theranostics.

Mater Sci Eng C Mater Biol Appl. 2017-1-1

[5]
Importance of doping, dopant distribution, and defects on electronic band structure alteration of metal oxide nanoparticles: Implications for reactive oxygen species.

Sci Total Environ. 2016-6-25

[6]
Photothermal Ablation of Cancer Cells Using Folate-Coated Gold/ Graphene Oxide Composite.

Curr Drug Deliv. 2017

[7]
Bioreducible branched poly(modified nona-arginine) cell-penetrating peptide as a novel gene delivery platform.

J Control Release. 2016-5-8

[8]
Fluorescent Cross-Linked Supramolecular Polymer Constructed by Orthogonal Self-Assembly of Metal-Ligand Coordination and Host-Guest Interaction.

Chemistry. 2016-5-10

[9]
Folic acid targeted Mn:ZnS quantum dots for theranostic applications of cancer cell imaging and therapy.

Int J Nanomedicine. 2016-1-22

[10]
Near-infrared photonic energy penetration: can infrared phototherapy effectively reach the human brain?

Neuropsychiatr Dis Treat. 2015-8-21

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