使用叶酸包被的金/氧化石墨烯复合材料对癌细胞进行光热消融
Photothermal Ablation of Cancer Cells Using Folate-Coated Gold/ Graphene Oxide Composite.
作者信息
Mauro Nicolò, Volsi Anna Li, Scialabba Cinzia, Licciardi Mariano, Cavallaro Gennara, Giammona Gaetano
机构信息
Laboratory of Biocompatible Polymers, Department of Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi, 32 90123 Palermo, Italy.
Laboratory of Biocompatible PolymeLaboratory of Biocompatible Polymers, Department of Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi, 32 90123 Palermo,rs, Department of Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), University of Palermo, Via Archirafi, 32 90123 Palermo, Italy. Italy.
出版信息
Curr Drug Deliv. 2017;14(3):433-443. doi: 10.2174/1567201813666160520113804.
OBJECTIVE
A new tumor targeted polymer-coated gold/graphene hybrid has been developed for achieving simultaneously thermoablation and chemoterapy of folate receptor-positive cancer cells.
METHODS
The gold/graphene hybrid was prepared by depositing gold nanospheres onto graphene oxide and coating it with an inulin-folate conjugate. Paclitaxel was loaded by sonication. The hybrid was characterized by UV-Vis spectroscopy, DSC analysis and SEM microscopy. The cytotoxicity, thermoablation and anticancer activity were evaluated in vitro on MCF-7 and 16 HBE.
RESULTS
In vitro tests showed that the paclitaxel-loaded hybrid improved the effectiveness of the drug especially after photothermal treatments.
CONCLUSION
On the whole, while gold/graphene composite provided an excellent time-dependent photothermal effect, the loading of paclitaxel allowed a suitable chemotherapy, thus killing cancer cells both via a selective laser beam thermoablation and hyperthermia-triggered chemotherapy.
目的
已开发出一种新型的肿瘤靶向聚合物包覆的金/石墨烯复合材料，用于同时实现对叶酸受体阳性癌细胞的热消融和化疗。
方法
通过将金纳米球沉积在氧化石墨烯上并用菊粉-叶酸共轭物包覆来制备金/石墨烯复合材料。通过超声处理加载紫杉醇。该复合材料通过紫外-可见光谱、差示扫描量热分析和扫描电子显微镜进行表征。在MCF-7和16HBE细胞上体外评估其细胞毒性、热消融和抗癌活性。
结果
体外试验表明，负载紫杉醇的复合材料提高了药物的有效性，尤其是在光热治疗后。
结论
总体而言，金/石墨烯复合材料提供了优异的时间依赖性光热效应，而紫杉醇的负载实现了合适的化疗，从而通过选择性激光束热消融和热疗触发的化疗杀死癌细胞。
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