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腹膜转移的姑息治疗。

Palliative Management of Peritoneal Metastases.

机构信息

Surgical Oncology, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, USA.

Division of Surgical Oncology, University of Massachusetts Medical School, Worcester, MA, USA.

出版信息

Ann Surg Oncol. 2018 Aug;25(8):2165-2171. doi: 10.1245/s10434-018-6335-7. Epub 2018 Jan 30.

Abstract

Despite significant recent advances in the management of peritoneal carcinomatosis, this diagnosis still is accompanied frequently by a grim survival prognosis, often measured in weeks to months. The poor prognosis also is accompanied often by complications and symptoms that have a dramatic impact on quality of life and are challenging to the managing health care provider and devastating to loved ones caring for the person who is suffering. Consequently, management of carcinomatosis often revolves around palliation of symptoms such as bowel obstruction, nausea, pain, fatigue, and cachexia as well as emotional and existential concerns. This article reviews several palliative treatment options for some of the more common symptoms and complications associated with advanced, incurable peritoneal carcinomatosis. Although readers should recognize that carcinomatosis is no longer an imminent death sentence, providers caring for patients with peritoneal carcinomatosis also must be well-versed in the palliative management of this condition and recognize the utility of early palliative care referral in this setting.

摘要

尽管在腹膜癌病的治疗方面取得了重大的进展,但这种诊断仍然常常伴随着严峻的生存预后,通常以数周到数月来衡量。较差的预后通常还伴随着并发症和症状,这些症状对生活质量有重大影响,给管理医疗服务提供者带来挑战,也给照顾患者的亲人带来毁灭性的打击。因此,癌病的治疗通常围绕着缓解症状,如肠梗阻、恶心、疼痛、疲劳和恶病质,以及情绪和存在问题。本文综述了一些姑息治疗方法,用于治疗晚期、不可治愈的腹膜癌病相关的一些常见症状和并发症。尽管读者应该认识到,癌病不再是一个迫在眉睫的死亡判决,但照顾腹膜癌病患者的提供者也必须精通这种疾病的姑息治疗,并认识到在这种情况下早期姑息治疗转介的实用性。

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