相互矛盾的观点：CNNM蛋白并非钠/镁交换体，而是在跨上皮镁（再）吸收中起核心作用的镁转运调节因子。 - Suppr

CrossTalk opposing view: CNNM proteins are not Na /Mg exchangers but Mg transport regulators playing a central role in transepithelial Mg (re)absorption.

作者信息

Arjona Francisco J, de Baaij Jeroen H F

机构信息

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

出版信息

J Physiol. 2018 Mar 1;596(5):747-750. doi: 10.1113/JP275249. Epub 2018 Jan 31.

DOI:10.1113/JP275249

PMID:29383729

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5830416/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/559b/5830416/75d9a2d3235e/TJP-596-747-g002.jpg

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CrossTalk opposing view: CNNM proteins are not Na /Mg exchangers but Mg transport regulators playing a central role in transepithelial Mg (re)absorption.

J Physiol. 2018 Mar 1;596(5):747-750. doi: 10.1113/JP275249. Epub 2018 Jan 31.

CrossTalk proposal: CNNM proteins are Na /Mg exchangers playing a central role in transepithelial Mg (re)absorption.

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Renal function of cyclin M2 Mg2+ transporter maintains blood pressure.

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EMBO Rep. 2016 Dec;17(12):1890-1900. doi: 10.15252/embr.201643393. Epub 2016 Nov 17.

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Sci Rep. 2016 Jun 28;6:28565. doi: 10.1038/srep28565.

Human CNNM2 is not a Mg(2+) transporter per se.

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Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.

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CrossTalk opposing view: CNNM proteins are not Na /Mg exchangers but Mg transport regulators playing a central role in transepithelial Mg (re)absorption.

作者信息

Arjona Francisco J, de Baaij Jeroen H F

机构信息

Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

出版信息

J Physiol. 2018 Mar 1;596(5):747-750. doi: 10.1113/JP275249. Epub 2018 Jan 31.

DOI:10.1113/JP275249

PMID:29383729

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5830416/

Abstract

摘要

相似文献

CrossTalk opposing view: CNNM proteins are not Na /Mg exchangers but Mg transport regulators playing a central role in transepithelial Mg (re)absorption.

J Physiol. 2018 Mar 1;596(5):747-750. doi: 10.1113/JP275249. Epub 2018 Jan 31.

CrossTalk proposal: CNNM proteins are Na /Mg exchangers playing a central role in transepithelial Mg (re)absorption.

J Physiol. 2018 Mar 1;596(5):743-746. doi: 10.1113/JP275248. Epub 2018 Jan 31.

Absorption and electrolyte changes of intestinal mucosa following substrate induction.

Am J Physiol. 1967 Mar;212(3):711-6. doi: 10.1152/ajplegacy.1967.212.3.711.

H/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na/H exchanger.

Gastroenterology. 2002 May;122(5):1322-33. doi: 10.1053/gast.2002.32992.

Ionic distribution and fluxes in holothurian tissues.

Comp Biochem Physiol A Comp Physiol. 1974 Apr 1;47(4):1153-70. doi: 10.1016/0300-9629(74)90090-5.

Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis.

EMBO Rep. 2016 Dec;17(12):1890-1900. doi: 10.15252/embr.201643393. Epub 2016 Nov 17.

PAT-1 (Slc26a6) is the predominant apical membrane Cl-/HCO3- exchanger in the upper villous epithelium of the murine duodenum.

Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1079-88. doi: 10.1152/ajpgi.00354.2006. Epub 2006 Dec 14.

Na+/Mg2+ transporter acts as a Mg2+ buffering mechanism in PC12 cells.

Biochem Biophys Res Commun. 2003 Mar 28;303(1):332-6. doi: 10.1016/s0006-291x(03)00346-2.

[On the problem of coupling between active sodium and monosaccharide transport in the small intestine mucosa].

Acta Biol Med Ger. 1967;18(5):555-61.

The emerging roles and therapeutic potential of cyclin M/CorC family of Mg transporters.

J Pharmacol Sci. 2022 Jan;148(1):14-18. doi: 10.1016/j.jphs.2021.09.004. Epub 2021 Sep 20.

引用本文的文献

Selective serotonin reuptake inhibitors (SSRIs) suppress Na- dependent Mg efflux in rat ventricular myocytes.

J Physiol Sci. 2025 Jul;75(2):100025. doi: 10.1016/j.jphyss.2025.100025. Epub 2025 May 12.

The PACT Network: PRL, ARL, CNNM, and TRPM Proteins in Magnesium Transport and Disease.

Int J Mol Sci. 2025 Feb 12;26(4):1528. doi: 10.3390/ijms26041528.

A distal convoluted tubule-specific isoform of murine SLC41A3 extrudes magnesium.

Acta Physiol (Oxf). 2025 Mar;241(3):e70018. doi: 10.1111/apha.70018.

Magnesium biology.

Nephrol Dial Transplant. 2024 Nov 27;39(12):1965-1975. doi: 10.1093/ndt/gfae134.

PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics.

Proc Natl Acad Sci U S A. 2023 Apr 4;120(14):e2221083120. doi: 10.1073/pnas.2221083120. Epub 2023 Mar 27.

Phosphatase-independent role of phosphatase of regenerating liver in cancer progression.

Cancer Sci. 2023 Jan;114(1):25-33. doi: 10.1111/cas.15625. Epub 2022 Nov 11.

A tonoplast-localized magnesium transporter is crucial for stomatal opening in Arabidopsis under high Mg conditions.

New Phytol. 2022 Nov;236(3):864-877. doi: 10.1111/nph.18410. Epub 2022 Aug 17.

Systematic in silico discovery of novel solute carrier-like proteins from proteomes.

PLoS One. 2022 Jul 28;17(7):e0271062. doi: 10.1371/journal.pone.0271062. eCollection 2022.

Novel Mutation Responsible for Autosomal-Dominant Hypomagnesemia With Seizure.

Front Genet. 2022 Jun 29;13:875013. doi: 10.3389/fgene.2022.875013. eCollection 2022.

Structural and functional comparison of magnesium transporters throughout evolution.

Cell Mol Life Sci. 2022 Jul 12;79(8):418. doi: 10.1007/s00018-022-04442-8.

本文引用的文献

Renal function of cyclin M2 Mg2+ transporter maintains blood pressure.

J Hypertens. 2017 Mar;35(3):585-592. doi: 10.1097/HJH.0000000000001211.

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival.

Elife. 2016 Dec 19;5:e20914. doi: 10.7554/eLife.20914.

Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis.

EMBO Rep. 2016 Dec;17(12):1890-1900. doi: 10.15252/embr.201643393. Epub 2016 Nov 17.

Identification of SLC41A3 as a novel player in magnesium homeostasis.

Sci Rep. 2016 Jun 28;6:28565. doi: 10.1038/srep28565.

Human CNNM2 is not a Mg(2+) transporter per se.

Pflugers Arch. 2016 Jul;468(7):1223-1240. doi: 10.1007/s00424-016-1816-7. Epub 2016 Apr 11.

Inhibition of PRL-2·CNNM3 Protein Complex Formation Decreases Breast Cancer Proliferation and Tumor Growth.

J Biol Chem. 2016 May 13;291(20):10716-25. doi: 10.1074/jbc.M115.705863. Epub 2016 Mar 11.

Magnesium in man: implications for health and disease.

Physiol Rev. 2015 Jan;95(1):1-46. doi: 10.1152/physrev.00012.2014.

Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression.

J Clin Invest. 2014 Dec;124(12):5398-410. doi: 10.1172/JCI76614. Epub 2014 Oct 27.

Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.

Biochem J. 2014 Nov 15;464(1):23-34. doi: 10.1042/BJ20140409.

Mg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporter.

J Biol Chem. 2014 May 23;289(21):14731-9. doi: 10.1074/jbc.M114.551176. Epub 2014 Apr 6.

CrossTalk opposing view: CNNM proteins are not Na /Mg exchangers but Mg transport regulators playing a central role in transepithelial Mg (re)absorption.

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CrossTalk opposing view: CNNM proteins are not Na /Mg exchangers but Mg transport regulators playing a central role in transepithelial Mg (re)absorption.

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