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CrossTalk proposal: CNNM proteins are Na /Mg exchangers playing a central role in transepithelial Mg (re)absorption.

作者信息

Funato Yosuke, Furutani Kazuharu, Kurachi Yoshihisa, Miki Hiroaki

机构信息

Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.

Department of Pharmacology, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan.

出版信息

J Physiol. 2018 Mar 1;596(5):743-746. doi: 10.1113/JP275248. Epub 2018 Jan 31.

Abstract
摘要

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本文引用的文献

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Renal function of cyclin M2 Mg2+ transporter maintains blood pressure.
J Hypertens. 2017 Mar;35(3):585-592. doi: 10.1097/HJH.0000000000001211.
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An Essential Factor for High Mg Tolerance of .
Front Microbiol. 2016 Nov 25;7:1888. doi: 10.3389/fmicb.2016.01888. eCollection 2016.
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Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.
J Biol Chem. 2017 Jan 20;292(3):786-801. doi: 10.1074/jbc.M116.759944. Epub 2016 Nov 29.
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Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis.
EMBO Rep. 2016 Dec;17(12):1890-1900. doi: 10.15252/embr.201643393. Epub 2016 Nov 17.
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Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.
PLoS Genet. 2016 Aug 26;12(8):e1006276. doi: 10.1371/journal.pgen.1006276. eCollection 2016 Aug.
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The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and is essential for reproduction.
J Cell Sci. 2016 May 1;129(9):1940-9. doi: 10.1242/jcs.182220. Epub 2016 Mar 22.
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Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression.
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Mg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporter.
J Biol Chem. 2014 May 23;289(21):14731-9. doi: 10.1074/jbc.M114.551176. Epub 2014 Apr 6.
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CNNM2 mutations cause impaired brain development and seizures in patients with hypomagnesemia.
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