Ruutiainen K, Erkkola R, Kaihola H L, Santti R, Irjala K
Acta Obstet Gynecol Scand. 1985;64(8):629-33. doi: 10.3109/00016348509158203.
The degree of hair growth of 64 hirsute women was clinically graded. The patients were divided into two groups with respect to the ratio between the serum luteinizing hormone (LH) and the follicle-stimulating hormone (FSH). The two groups did not differ in terms of the grade of hirsutism, serum testosterone (T), calculated free testosterone (FTc), androstenedione (A), dehydroepiandrosterone sulphate (DHEAS), sex hormone binding globulin (SHBG), estradiol, or cortisol levels. In patients with a LH/FSH ratio of 3.0 or less (n = 49), FTc and A correlated well (rho 0.49, p less than 0.001) to the clinically graded hormonal hirsutism score, while SHBG showed an inverse correlation to it. By contrast, no correlations were found in patients with a serum LH/FSH ratio exceeding 3.0 (n = 15). Various indices for hyperandrogenism were calculated. In patients with lower LH/FSH ratio, T/SHBG, T/SHBG + A/100 and T/SHBG + A/100 + DHEAS/100 showed the best correlation with the clinically scored hair growth. These results show that correlations between hirsutism and hyperandrogenism can be demonstrated.
对64名多毛女性的毛发生长程度进行了临床分级。根据血清促黄体生成素（LH）与促卵泡生成素（FSH）的比值，将患者分为两组。两组在多毛症分级、血清睾酮（T）、计算的游离睾酮（FTc）、雄烯二酮（A）、硫酸脱氢表雄酮（DHEAS）、性激素结合球蛋白（SHBG）、雌二醇或皮质醇水平方面无差异。在LH/FSH比值为3.0或更低的患者（n = 49）中，FTc和A与临床分级的激素性多毛症评分相关性良好（rho 0.49，p小于0.001），而SHBG与之呈负相关。相比之下，在血清LH/FSH比值超过3.0的患者（n = 15）中未发现相关性。计算了各种高雄激素血症指标。在LH/FSH比值较低的患者中，T/SHBG、T/SHBG + A/100和T/SHBG + A/100 + DHEAS/100与临床评分的毛发生长相关性最佳。这些结果表明多毛症与高雄激素血症之间存在相关性。
