Ruutiainen K
Int J Gynaecol Obstet. 1986 Oct;24(5):361-8. doi: 10.1016/0020-7292(86)90156-6.
A group of 22 hirsute women was treated with a combination of 0.030 mg of ethinylestradiol and 0.150 mg of desogestrel (EE-DG) for 6 or 12 months. After 6 months the hair growth was decreased in 17 patients. There was a significant decrease in testosterone/sex hormone binding globulin (T/SHBG) ratio and serum dehydroepiandrosterone sulphate (DHEAS) levels. The changes in the hirsutism and the T/SHBG ratio showed correlation (rho 0.36, P less than 0.05). The patient groups with the best and the poorest clinical response differed in terms of summed changes in the T/SHBG ratio and DHEAS. These findings suggest that the therapeutic effect of the EE-DG is based on combined changes in the related hormone levels.
一组22名多毛症女性接受了0.030毫克乙炔雌二醇和0.150毫克去氧孕烯(EE-DG)联合治疗6个月或12个月。6个月后,17名患者的毛发生长减少。睾酮/性激素结合球蛋白(T/SHBG)比值和血清硫酸脱氢表雄酮(DHEAS)水平显著降低。多毛症的变化与T/SHBG比值显示出相关性(rho 0.36,P<0.05)。临床反应最佳和最差的患者组在T/SHBG比值和DHEAS的总体变化方面存在差异。这些发现表明,EE-DG的治疗效果基于相关激素水平的联合变化。