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一种含有炔雌醇和去氧孕烯的口服避孕药对多毛症女性毛发生长和激素参数的影响。

The effect of an oral contraceptive containing ethinylestradiol and desogestrel on hair growth and hormonal parameters of hirsute women.

作者信息

Ruutiainen K

出版信息

Int J Gynaecol Obstet. 1986 Oct;24(5):361-8. doi: 10.1016/0020-7292(86)90156-6.

DOI:10.1016/0020-7292(86)90156-6
PMID:2880770
Abstract

A group of 22 hirsute women was treated with a combination of 0.030 mg of ethinylestradiol and 0.150 mg of desogestrel (EE-DG) for 6 or 12 months. After 6 months the hair growth was decreased in 17 patients. There was a significant decrease in testosterone/sex hormone binding globulin (T/SHBG) ratio and serum dehydroepiandrosterone sulphate (DHEAS) levels. The changes in the hirsutism and the T/SHBG ratio showed correlation (rho 0.36, P less than 0.05). The patient groups with the best and the poorest clinical response differed in terms of summed changes in the T/SHBG ratio and DHEAS. These findings suggest that the therapeutic effect of the EE-DG is based on combined changes in the related hormone levels.

摘要

一组22名多毛症女性接受了0.030毫克乙炔雌二醇和0.150毫克去氧孕烯（EE-DG）联合治疗6个月或12个月。6个月后，17名患者的毛发生长减少。睾酮/性激素结合球蛋白（T/SHBG）比值和血清硫酸脱氢表雄酮（DHEAS）水平显著降低。多毛症的变化与T/SHBG比值显示出相关性（rho 0.36，P<0.05）。临床反应最佳和最差的患者组在T/SHBG比值和DHEAS的总体变化方面存在差异。这些发现表明，EE-DG的治疗效果基于相关激素水平的联合变化。

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1
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2
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