Mosca S M, Gelpi R J, Cingolani H E
Acta Physiol Pharmacol Latinoam. 1985;35(3):361-73.
Some aspects of hemodynamic effects and distribution of coronary flow of molsidomine were evaluated in anesthetized dogs with open chest. Three experimental groups were performed: In groups I and II 100 micrograms/kg and 200 micrograms/kg of molsidomine were administered respectively. Cardiac output (CO), end diastolic pressure (EDP), mean arterial pressure (MAP), heart rate (HR), systolic left ventricular pressure (SLVP), their maximal rates of development and fall (+P and -P, respectively), developed tension (DT), their maximal contraction (+T) and relaxation (-T) rates, were measured. Peripheral resistance (PR) and the ratios +P/-P and +T/-T were calculated. In group III 100 micrograms/kg of molsidomine were administered after the ligature of the anterior descendent artery (AD) was performed. In this group the distribution of coronary flow was measured through radioactive microspheres injection in the circumflex area (CX) (normal area) and in the AD area (ischemic area). After injecting the microspheres and following its effects for one hour, the maximum effect was determined in 30 minutes. Heart rate did not show any statistically significant variation at any of the doses used. MAP fell from 92 +/- 3 mmHg to 77 +/- 5 mmHg (P less than 0.05) in group I and from 87 +/- 3 mmHg to 69 +/- 4 mmHg in group II. Cardiac output fell from 1.63 +/- 0.13 1/min to 1.22 +/- 0.12 1/min (P less than 0.05) in group I and from 1.60 +/- 0.19 1/min to 1.13 +/- 0.18 1/min (P less than 0.05) in group II. PR did not show any significant change in any of the groups. +P decreased 13 +/- 6% (P less than 0.05) in group I and 13 +/- 5% (P less than 0.05) in group II. The decrease of -P was of 17 +/- 5% (P less than 0.05) in both groups. EDP decreased from 6.0 +/- 1.0 mmHg to 3.9 +/- 0.9 mmHg (P less than 0.05) and from 5.5 +/- 0.5 mmHg to 2.9 +/- 0.8 mmHg (P less than 0.05) in groups I and II, respectively. DT, +T, -T, +T/-T and +P/-P did not show any significant change. EDP fell from 8 +/- 1 mmHg to 4.1 +/- 1.3 mmHg (P less than 0.05); MAP fell from 82 +/- 4 mmHg to 62 +/- 6 mmHg (P less than 0.05) and CO fell from 2.05 +/- 0.27 1/min to 1.30 +/- 0.14 1/min in group III. HR and PR did not show any significant change in group III.(ABSTRACT TRUNCATED AT 400 WORDS)
在开胸麻醉犬身上评估了吗多明的血流动力学效应及冠状动脉血流分布的某些方面。进行了三个实验组：在第一组和第二组中，分别给予100微克/千克和200微克/千克的吗多明。测量心输出量（CO）、舒张末期压力（EDP）、平均动脉压（MAP）、心率（HR）、左心室收缩压（SLVP）、它们的最大上升和下降速率（分别为+P和-P）、发展张力（DT）、它们的最大收缩（+T）和舒张（-T）速率。计算外周阻力（PR）以及+P/-P和+T/-T的比值。在第三组中，在结扎前降支动脉（AD）后给予100微克/千克的吗多明。在该组中，通过在回旋支区域（CX）（正常区域）和AD区域（缺血区域）注射放射性微球来测量冠状动脉血流分布。注射微球并观察其作用一小时后，在30分钟时确定最大效应。在所使用的任何剂量下，心率均未显示出任何统计学上的显著变化。在第一组中，MAP从92±3毫米汞柱降至77±5毫米汞柱（P＜0.05），在第二组中从87±3毫米汞柱降至69±4毫米汞柱。在第一组中，心输出量从1.63±0.13升/分钟降至1.22±0.12升/分钟（P＜0.05），在第二组中从1.60±0.19升/分钟降至1.13±0.18升/分钟（P＜0.05）。在任何一组中，PR均未显示出任何显著变化。在第一组中，+P降低了13±6%（P＜0.05），在第二组中降低了13±5%（P＜0.05）。在两组中，-P的降低均为17±5%（P＜0.05）。在第一组和第二组中，EDP分别从6.0±1.0毫米汞柱降至3.9±0.9毫米汞柱（P＜0.05）和从5.5±0.5毫米汞柱降至2.9±0.8毫米汞柱（P＜0.05）。DT、+T、-T、+T/-T和+P/-P均未显示出任何显著变化。在第三组中，EDP从8±1毫米汞柱降至4.1±1.3毫米汞柱（P＜0.05）；MAP从82±4毫米汞柱降至62±6毫米汞柱（P＜0.05），CO从2.05±0.27升/分钟降至1.30±0.14升/分钟。在第三组中，HR和PR均未显示出任何显著变化。（摘要截于400字）
