Sakagami K, Takeuchi H, Tsuboi K, Matsumoto T, Tanaka K, Ohsaki T, Horimi T, Fuchimoto S, Orita K
Acta Med Okayama. 1986 Feb;40(1):39-43. doi: 10.18926/AMO/31939.
The survival rate of 19 patients who underwent living-related kidney transplantation after donor-specific blood transfusions (DST) was compared with that of 32 historical controls receiving transplants without DST. The graft survival rate of the DST group was 82% after two and three years. The graft survival rate of the DST group was significantly better than the 53% rate after two years obtained with the 32 historical controls (p less than 0.05). We tested sera from 16 DST-treated recipients to study the beneficial effect of DST on kidney allograft survival using the mixed lymphocyte culture (MLC) serum inhibition test. The results demonstrated that MLC inhibitory factors were induced in the serum of the recipient after completion of DST. This inhibition of MLC was observed by treatment of responder lymphocytes with serum obtained three weeks after DST plus rabbit complement. The inhibitory effect was also specific for responder cells in anti-donor MLC. Regarding the correlation with rejection episodes, these MLC inhibitory factors were often observed in the non-rejection group (p less than 0.05). The data suggest that such factors may be anti-idiotypic antibodies and be associated with prolonged graft survival.
将接受供体特异性输血（DST）后进行亲属活体肾移植的19例患者的存活率与32例未接受DST进行移植的历史对照患者的存活率进行比较。DST组在两年和三年后的移植物存活率为82%。DST组的移植物存活率显著高于32例历史对照患者在两年后获得的53%的存活率（p<0.05）。我们检测了16例接受DST治疗的受者的血清，使用混合淋巴细胞培养（MLC）血清抑制试验研究DST对肾移植存活的有益作用。结果表明，在DST完成后，受者血清中诱导出了MLC抑制因子。通过用DST三周后获得的血清加兔补体处理反应性淋巴细胞，观察到了这种对MLC的抑制作用。这种抑制作用在抗供体MLC中对反应性细胞也是特异性的。关于与排斥反应发作的相关性，这些MLC抑制因子在非排斥组中经常观察到（p<0.05）。数据表明，这些因子可能是抗独特型抗体，并与移植物长期存活相关。
