Department of Organic Chemistry, Indian Association for the Cultivation of Science , Jadavpur, Kolkata 700032, India.
Org Lett. 2018 Feb 16;20(4):1011-1014. doi: 10.1021/acs.orglett.7b03955. Epub 2018 Jan 31.
A cobalt-catalyzed selective remote C-4 alkylation of 8-aminoquinoline amides via C-H activation under irradiation with a CFL lamp in the presence of eosin Y at room temperature has been achieved. A series of pharmaceutically important C-4 quinoline amide-substituted ether derivatives has been obtained by this procedure. The C-4 functionalization of quinoline amides with inert ether is of much significance and was not reported earlier.
在室温下，通过 CFL 灯照射并使用曙红 Y 作为光催化剂，钴催化实现了 8-氨基喹啉酰胺的选择性远程 C-4 烷基化反应，该反应通过 C-H 活化进行。通过该方法得到了一系列具有重要药物意义的 C-4 喹啉酰胺取代醚衍生物。此前尚未有报道过使用惰性醚对喹啉酰胺进行 C-4 官能化，因此该反应具有重要意义。
