微小RNA在结直肠癌不同阶段的表达及意义
The expression and significance of microRNA in different stages of colorectal cancer.
作者信息
Du Binbin, Wu Dewang, Yang Xiongfei, Wang Tao, Shi Xinlong, Lv Yaochun, Zhou Zhuolong, Liu Qing, Zhang Weisheng
机构信息
Department of Colorectal Surgery, Gansu Provincial Hospital, Lanzhou Department of Surgery, Ningxia Medical University, Yinchuan School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China.
出版信息
Medicine (Baltimore). 2018 Feb;97(5):e9635. doi: 10.1097/MD.0000000000009635.
BACKGROUND
The aim of this study is to compare microRNA expression patterns in different stages of colorectal cancer (CRC) and to discuss the significance of the application of microRNAs in the clinical treatment of CRC.
METHODS
The study used gene chip technology to analyze genetic sequences in CRC tissues and surrounding normal tissues at different cancer stages. The bioinformatics profiles of the target genes of the different microRNAs were analyzed to clarify the target gene-related pathways and their functions in the disease.
RESULTS
A total of 368 target genes with differential expression, including 275 upregulated and 93 downregulated genes, were screened from CRC patients in different stages of the disease. These microRNAs participated widely in the occurrence and development processes of CRC. The microRNA expression profiles obviously differed in tissues at different CRC stages.
CONCLUSION
microRNA regulation of CRC samples can be used as a tool to control the occurrence and development of tumor cells.
背景
本研究旨在比较结直肠癌（CRC）不同阶段的微小RNA表达模式，并探讨微小RNA在CRC临床治疗中的应用意义。
方法
本研究采用基因芯片技术分析不同癌症阶段CRC组织及周围正常组织中的基因序列。分析不同微小RNA靶基因的生物信息学图谱，以阐明靶基因相关通路及其在疾病中的功能。
结果
从不同疾病阶段的CRC患者中筛选出368个差异表达的靶基因，其中275个上调基因和93个下调基因。这些微小RNA广泛参与CRC的发生和发展过程。不同CRC阶段组织中的微小RNA表达谱明显不同。
结论
CRC样本的微小RNA调控可作为控制肿瘤细胞发生和发展的工具。
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