Ye Lin, Wang Guobin, Tang Yong, Bai Jie
Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, HuaZhong University of Science and Technology, 1277 JieFang Avenue, Wuhan, 430022, China.
Int J Clin Oncol. 2017 Apr;22(2):307-315. doi: 10.1007/s10147-016-1044-3. Epub 2016 Oct 4.
Many epidemiological studies have investigated the correlation between adiponectin, C1Q and collagen domain containing (ADIPOQ) single nucleotide polymorphisms (SNPs) and risk of colorectal cancer (CRC). Although conflicting results have been reported, there was dispute regarding two SNPs (rs2241766 T/G and rs1501299 G/T). Therefore, we conducted a meta-analysis to systematically assess the associations and try to find the reasons for the dispute.
We searched PubMed, the Cochrane Library, Elsevier, Wiley Online Library, China National Knowledge Infrastructure, WanFang data and Chongqing VIP to search for all eligible case-control studies published up to January 2015. Effect sizes of odds ratios (OR) and 95 % confidence intervals (95 % CI) were calculated using a fixed- or random-effect model.
Ten case-control studies including 4377 cases and 5584 controls were selected. A significant difference was observed in Chinese (OR 0.76; 95 % CI 0.68, 0.85; P < 0.001) and Ashkenazi Jewish populations (OR 0.79; 95 % CI 0.63, 0.99; P = 0.04) for rs2241766 with dominant model (TT vs TG + GG). A significant difference was observed in the Chinese population (OR 1.23; 95 % CI 1.11, 1.37; P < 0.001) for rs1501299 with dominant model (TT vs TG + GG). In addition, intake of red meat showed a synergistic effect between ADIPOQ gene and risk of colorectal cancer (CRC).
ADIPOQ SNPs rs2241766 T/G and rs 1501299 G/T have a population-specific correlation with risk of CRC. However, small sample studies may increase reporting bias, particularly if the total number of studies included in the analysis is small.
许多流行病学研究调查了脂联素、含C1Q和胶原结构域（ADIPOQ）单核苷酸多态性（SNP）与结直肠癌（CRC）风险之间的相关性。尽管已有相互矛盾的结果报道，但对于两个SNP（rs2241766 T/G和rs1501299 G/T）仍存在争议。因此，我们进行了一项荟萃分析，以系统评估这些关联，并试图找出争议的原因。
我们检索了PubMed、Cochrane图书馆、爱思唯尔、威利在线图书馆、中国知网、万方数据和维普资讯，以查找截至2015年1月发表的所有符合条件的病例对照研究。使用固定效应或随机效应模型计算比值比（OR）和95%置信区间（95%CI）的效应量。
选取了10项病例对照研究，包括4377例病例和5584例对照。对于rs2241766，在显性模型（TT与TG+GG）下，中国人群（OR 0.76；95%CI 0.68，0.85；P<0.001）和阿什肯纳兹犹太人群（OR 0.79；95%CI 0.63，0.99；P=0.04）中观察到显著差异。对于rs1501299，在显性模型（TT与TG+GG）下，中国人群（OR 1.23；95%CI 1.11，1.37；P<0.001）中观察到显著差异。此外，红肉摄入显示出ADIPOQ基因与结直肠癌（CRC）风险之间的协同效应。
ADIPOQ SNP rs2241766 T/G和rs1501299 G/T与CRC风险存在人群特异性相关性。然而，小样本研究可能会增加报告偏倚，特别是在分析中纳入的研究总数较少时。
