Kosinski Tracy M, Brown Michael C, Zavala Pedro J
Concordia University of Wisconsin School of Pharmacy, Mequon, Wisconsin.
Int J Pharm Compd. 2018 Jan-Feb;22(1):41-46.
The purpose of this study was to investigate the accuracy and reproducibility of a 2-mL volume injection using a 3-mL and 10-mL syringe with pharmacy student compounders. An exercise was designed to assess each student's accuracy in compounding a sterile preparation with the correct 4-mg strength using a 3-mL and 10-mL syringe. The average ondansetron dose when compounded with the 3-mL syringe was 4.03 mg (standard deviation ± 0.45 mg), which was not statistically significantly different than the intended 4-mg desired dose (P=0.497). The average ondansetron dose when compounded with the 10-mL syringe was 4.18 mg (standard deviation + 0.68 mg), which was statistically significantly different than the intended 4-mg desired dose (P=0.002). Additionally, there also was a statistically significant difference in the average ondansetron dose compounded using a 3-mL syringe (4.03 mg) and a 10-mL syringe (4.18 mg) (P=0.027). The accuracy and reproducibility of the 2-mL desired dose volume decreased as the compounding syringe size increased from 3 mL to 10 mL.
本研究的目的是调查药学专业学生在使用3毫升和10毫升注射器进行2毫升体积注射时的准确性和可重复性。设计了一项练习，以评估每位学生使用3毫升和10毫升注射器配制4毫克正确浓度无菌制剂时的准确性。使用3毫升注射器配制时，昂丹司琼的平均剂量为4.03毫克（标准差±0.45毫克），与预期的4毫克目标剂量相比，差异无统计学意义（P=0.497）。使用10毫升注射器配制时，昂丹司琼的平均剂量为4.18毫克（标准差+0.68毫克），与预期的4毫克目标剂量相比，差异有统计学意义（P=0.002）。此外，使用3毫升注射器（4.03毫克）和10毫升注射器（4.18毫克）配制的昂丹司琼平均剂量也有统计学差异（P=0.027）。随着配制注射器尺寸从3毫升增加到10毫升，2毫升目标剂量体积的准确性和可重复性降低。
