Shiraishi Naoyuki, Kinoshita Makoto, Shimizu Mikito, Sumikura Hiroyuki, Fukada Kei
Department of Neurology, Osaka General Medical Center.
Department of Neurology, Osaka University.
Rinsho Shinkeigaku. 2018 Feb 28;58(2):127-130. doi: 10.5692/clinicalneurol.cn-001104. Epub 2018 Jan 31.
At 37 years of age, the patient initially presented with symptoms of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) during her 1st pregnancy. She was treated with intravenous immunoglobulin (IVIg), and showed favorable recovery, becoming almost asymptomatic by the age of 38. At 39 years of age, during her puerperal period of her second pregnancy, she developed symmetrical muscle weakness and sensory disturbance of the upper and lower limbs. Nerve conduction studies revealed diffuse demyelination of peripheral nerves, and she was diagnosed with recurrence of CIDP. Once again, she showed remarkable improvement after IVIg therapy, and she has remained asymptomatic without the induction of preventative therapies. Recurrence of CIDP triggered in accordance with multiple pregnancies is extremely rare, and its clinical and electrophysiological features are presented in this report.
37岁时，该患者在首次怀孕期间最初出现慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）症状。她接受了静脉注射免疫球蛋白（IVIg）治疗，恢复良好，到38岁时几乎无症状。39岁时，在她第二次怀孕的产褥期，她出现了对称性肌肉无力以及上下肢感觉障碍。神经传导研究显示周围神经弥漫性脱髓鞘，她被诊断为CIDP复发。再次接受IVIg治疗后，她再次表现出显著改善，并且在未采用预防性治疗的情况下一直无症状。CIDP因多次怀孕而引发复发极为罕见，本报告呈现了其临床和电生理特征。
