[沃纳综合征中淋巴细胞的诱变敏感性与修复过程]
[Mutagen sensitivity and the repair process of the lymphocytes in the Werner syndrome].
作者信息
Deknudt G, Verellen-Dumoulin C, Léonard A
出版信息
C R Seances Soc Biol Fil. 1985;179(4):518-21.
PMID:2938680
Abstract
In this study, we analyzed the cell cycle kinetics, the radiosensitivity, the repair process and the induction of sister chromatid exchanges in lymphocytes from the Werner's syndrome. When compared to a normal population, no statistical significant differences were observed for the cell cycle kinetics and the radiosensitivity. However, differences exist with respect to the repair process and lymphocytes from the Werner's syndrome are much more sensitive to the induction of SCE's.
摘要
在本研究中，我们分析了沃纳综合征患者淋巴细胞的细胞周期动力学、放射敏感性、修复过程以及姐妹染色单体交换的诱导情况。与正常人群相比，在细胞周期动力学和放射敏感性方面未观察到统计学上的显著差异。然而，在修复过程方面存在差异，沃纳综合征患者的淋巴细胞对姐妹染色单体交换的诱导更为敏感。
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