Liechty Emma R, Bergin Ingrid L, Bell Jason D
Unit for Laboratory Animal Medicine.
Program on Women's Health Care Effectiveness Research, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Open Access J Contracept. 2015 Apr 17;6:27-35. doi: 10.2147/OAJC.S58754. eCollection 2015.
Appropriate animal modeling is vital for the successful development of novel contraceptive devices. Advances in reproductive biology have identified novel pathways for contraceptive intervention. Here we review species-specific anatomic and physiologic considerations impacting preclinical contraceptive testing, including efficacy testing, mechanistic studies, device design, and modeling off-target effects. Emphasis is placed on the use of nonhuman primate models in contraceptive device development.
合适的动物模型对于新型避孕装置的成功研发至关重要。生殖生物学的进展已确定了避孕干预的新途径。在此，我们综述了影响临床前避孕测试的物种特异性解剖学和生理学因素，包括功效测试、机制研究、装置设计以及脱靶效应建模。重点在于非人灵长类动物模型在避孕装置研发中的应用。
