避孕的动物模型：效用与局限性。
Animal models of contraception: utility and limitations.
作者信息
Liechty Emma R, Bergin Ingrid L, Bell Jason D
机构信息
Unit for Laboratory Animal Medicine.
Program on Women's Health Care Effectiveness Research, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
出版信息
Open Access J Contracept. 2015 Apr 17;6:27-35. doi: 10.2147/OAJC.S58754. eCollection 2015.
Abstract
Appropriate animal modeling is vital for the successful development of novel contraceptive devices. Advances in reproductive biology have identified novel pathways for contraceptive intervention. Here we review species-specific anatomic and physiologic considerations impacting preclinical contraceptive testing, including efficacy testing, mechanistic studies, device design, and modeling off-target effects. Emphasis is placed on the use of nonhuman primate models in contraceptive device development.
摘要
合适的动物模型对于新型避孕装置的成功研发至关重要。生殖生物学的进展已确定了避孕干预的新途径。在此，我们综述了影响临床前避孕测试的物种特异性解剖学和生理学因素，包括功效测试、机制研究、装置设计以及脱靶效应建模。重点在于非人灵长类动物模型在避孕装置研发中的应用。
相似文献
1
Animal models of contraception: utility and limitations.
Open Access J Contracept. 2015 Apr 17;6:27-35. doi: 10.2147/OAJC.S58754. eCollection 2015.
2
[Historical survey of modern reversible contraceptive methods].
Imbonezamuryango. 1986 Apr(5):14-7.
3
Clinical evaluation of drugs used in fertility regulation.
Hum Reprod. 1986 Sep;1(6):405-10. doi: 10.1093/oxfordjournals.humrep.a136436.
4
[Information on advances in sciences and technology. Advances in contraceptive technology].
Bol Cent Biol Reprod. 1993;12(1):51-2.
5
Canadian Contraception Consensus (Part 1 of 4).
J Obstet Gynaecol Can. 2015 Oct;37(10):936-42. doi: 10.1016/s1701-2163(16)30033-0.
6
Canadian Contraception Consensus (Part 2 of 4).
J Obstet Gynaecol Can. 2015 Nov;37(11):1033-9. doi: 10.1016/s1701-2163(16)30054-8.
7
Acceptability of an experimental intracervical device: results of a study controlling for selection bias.
Contraception. 1989 Jan;39(1):73-84. doi: 10.1016/0010-7824(89)90016-4.
8
Non-hormonal male contraception: A review and development of an Eppin based contraceptive.
Pharmacol Ther. 2016 Jan;157:105-11. doi: 10.1016/j.pharmthera.2015.11.004. Epub 2015 Nov 22.
9
Adolescent contraception. Review and recommendations.
Clin Pediatr (Phila). 1983 May;22(5):337-41. doi: 10.1177/000992288302200503.
10
Long-acting reversible contraception in adolescents: a systematic review and meta-analysis.
Am J Obstet Gynecol. 2017 Apr;216(4):364.e1-364.e12. doi: 10.1016/j.ajog.2016.12.024. Epub 2016 Dec 28.
引用本文的文献
1
Drug and therapeutic intravaginal delivery targeting diseases in the female reproductive tract: A mathematical modeling perspective.
J Control Release. 2025 Aug 10;384:113924. doi: 10.1016/j.jconrel.2025.113924. Epub 2025 Jun 2.
2
The effect of norethisterone acetate on the uterine telocytes, immune cells and progesterone receptors in albino rats.
Sci Rep. 2025 Mar 15;15(1):8997. doi: 10.1038/s41598-025-92354-5.
3
Long-acting reversible contraception with etonogestrel implants in female macaques ( and ).
Front Vet Sci. 2024 Jan 8;10:1319862. doi: 10.3389/fvets.2023.1319862. eCollection 2023.
4
Development of Gram Stain Scoring System Based on Pro-Inflammatory Cytokines in the Sheep Model for Testing Toxicity of Vaginal Products.
Front Reprod Health. 2021 Dec 6;3:714798. doi: 10.3389/frph.2021.714798. eCollection 2021.
5
Characterization of the Ovine Vaginal Microbiome and Inflammation Patterns as an Improved Testing Model of Human Vaginal Irritation.
Front Reprod Health. 2021 Dec 7;3:714829. doi: 10.3389/frph.2021.714829. eCollection 2021.
6
Drug Eluting Embolization Particles for Permanent Contraception.
ACS Biomater Sci Eng. 2022 Jul 11;8(7):2995-3009. doi: 10.1021/acsbiomaterials.2c00357. Epub 2022 Jun 24.
7
Adolescent Development of Biological Rhythms in Female Rats: Estradiol Dependence and Effects of Combined Contraceptives.
Front Physiol. 2021 Nov 5;12:752363. doi: 10.3389/fphys.2021.752363. eCollection 2021.
8
Development of multipurpose technologies products for pregnancy and STI prevention: update on polyphenylene carboxymethylene MPT gel development†.
Biol Reprod. 2020 Aug 4;103(2):299-309. doi: 10.1093/biolre/ioaa087.
本文引用的文献
1
Primate vaginal microbiomes exhibit species specificity without universal Lactobacillus dominance.
ISME J. 2014 Dec;8(12):2431-44. doi: 10.1038/ismej.2014.90. Epub 2014 Jul 18.
2
Obesity and contraception.
Clin Obstet Gynecol. 2014 Sep;57(3):501-7. doi: 10.1097/GRF.0000000000000047.
3
Simultaneous prevention of unintended pregnancy and STIs: a challenging compromise.
Hum Reprod Update. 2014 Nov-Dec;20(6):952-63. doi: 10.1093/humupd/dmu030. Epub 2014 Jun 16.
4
Young women's attitudes towards, and experiences of, long-acting reversible contraceptives.
Eur J Contracept Reprod Health Care. 2014 Aug;19(4):276-84. doi: 10.3109/13625187.2014.917623. Epub 2014 Jun 2.
5
Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir.
J Antimicrob Chemother. 2014 Sep;69(9):2477-88. doi: 10.1093/jac/dku160. Epub 2014 May 26.
6
Disrupting the male germ line to find infertility and contraception targets.
Ann Endocrinol (Paris). 2014 May;75(2):101-8. doi: 10.1016/j.ando.2014.04.006. Epub 2014 Apr 30.
7
A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques.
Hum Reprod. 2014 Jul;29(7):1400-12. doi: 10.1093/humrep/deu083. Epub 2014 Apr 29.
8
Increased susceptibility to vaginal simian/human immunodeficiency virus transmission in pig-tailed macaques coinfected with Chlamydia trachomatis and Trichomonas vaginalis.
J Infect Dis. 2014 Oct 15;210(8):1239-47. doi: 10.1093/infdis/jiu240. Epub 2014 Apr 21.
9
Exploring young adults' contraceptive knowledge and attitudes: disparities by race/ethnicity and age.
Womens Health Issues. 2014 May-Jun;24(3):e281-9. doi: 10.1016/j.whi.2014.02.003. Epub 2014 Apr 13.
10
Non-human primate models of hormonal contraception and HIV.
Am J Reprod Immunol. 2014 Jun;71(6):513-22. doi: 10.1111/aji.12246. Epub 2014 Apr 10.
Zotero 插件