Wildemeersch Dirk, Goldstuck Norman D
Gynecological Outpatient Clinic and IUD Training Center, Ghent, Belgium.
Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, Western Cape, South Africa.
Open Access J Contracept. 2015 Jul 9;6:87-94. doi: 10.2147/OAJC.S87607. eCollection 2015.
Early intrauterine device (IUD) discontinuation after insertion immediately following aspiration abortion or after early medical abortion occurs as a consequence of expulsion of the IUD or removal due to side effects. These are often the consequence of the uterine forces impacting on the IUD due to spatial discrepancy with the uterine cavity causing pain, abnormal bleeding, and eventually, removal of the IUD. These women are candidates for repeat pregnancy as they often select less-effective methods or no contraception at all. Repeat abortion could be reduced by giving attention to these factors.
In order to have an indication on the magnitude of the problem of IUD expulsion or discontinuation, we searched the MEDLINE database for clinical trials, randomized controlled trials, and prospective observational studies related to immediate postaspiration termination of pregnancy (TOP) and early medical abortion IUD insertion studies that reported IUD expulsion and IUD continuation rates.
The search identified 17 clinical trials that were suitable based on the data they presented. The majority concerned T-shape IUDs, inserted immediately following surgical (aspiration) pregnancy termination. Two studies were conducted after medical TOP, and four studies were conducted with the frameless IUD inserted after surgical (vacuum aspiration) TOP. The results showed expulsion rates between 0.8% and 17.3% at 8 weeks, up to 5 years after insertion, respectively. In four studies with the frameless IUD, totaling 553 insertions, the expulsion rate was 0.0% in three of them. Follow-up in the latter studies varied between 5 weeks and 54 months. Reported continuation rates with conventional (framed) IUDs were between 33.8% and 80% at 1 year for studies providing 1 year rates and between 68% and 94.1% for studies reporting continuation rates at 6 months. Studies utilizing frameless IUDs reported 1 year continuation rate over 95%.
Frameless IUDs, due to their attachment to the uterine fundus, appear to be better retained by the postabortal uterus when compared with conventional framed IUDs. The absence of a frame ensures compatibility with uterine cavity anatomical dimensions, and may therefore result in improved acceptability and continuation rates in comparison with framed IUDs. Both these characteristics of the frameless IUD could help reduce the number of repeat unwanted pregnancies and subsequent abortions in some cases.
在人工流产吸宫术后或早期药物流产后立即放置宫内节育器(IUD),早期取出IUD是由于IUD排出或因副作用而取出。这些情况通常是由于IUD与子宫腔空间不匹配,子宫收缩力作用于IUD,导致疼痛、异常出血,最终取出IUD。这些女性是再次怀孕的高危人群,因为她们通常选择效果较差的避孕方法或根本不采取避孕措施。关注这些因素可以减少重复流产的发生。
为了了解IUD排出或取出问题的严重程度,我们在MEDLINE数据库中搜索了与人工流产术后立即放置IUD及早期药物流产后放置IUD相关的临床试验、随机对照试验和前瞻性观察研究,这些研究报告了IUD排出率和IUD持续使用率。
搜索确定了17项基于所提供数据合适的临床试验。大多数研究涉及T型IUD,在手术(吸宫)终止妊娠后立即放置。两项研究在药物流产后进行,四项研究在手术(真空吸宫)终止妊娠后放置无支架IUD。结果显示,在放置后8周时排出率在0.8%至17.3%之间,最长随访至放置后5年。在四项使用无支架IUD的研究中,共放置553例,其中三项研究的排出率为0.0%。后几项研究的随访时间在5周至54个月之间。对于提供1年使用率的研究,传统(有支架)IUD报告的1年持续使用率在33.8%至80%之间,对于报告6个月持续使用率的研究,持续使用率在68%至94.1%之间。使用无支架IUD的研究报告1年持续使用率超过95%。
与传统有支架IUD相比,无支架IUD由于附着于子宫底部,似乎在流产后子宫中保留得更好。无支架设计确保了与子宫腔解剖尺寸的兼容性,因此与有支架IUD相比,可能会提高可接受性和持续使用率。无支架IUD的这两个特点在某些情况下有助于减少重复意外妊娠和后续流产的数量。