Markota Matej, Morgan Robert J
Department of Psychiatry and Psychology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Case Rep Psychiatry. 2017;2017:6045017. doi: 10.1155/2017/6045017. Epub 2017 Dec 14.
Gabapentin is frequently used in the treatment of anxiety disorders. However, there are no randomized controlled trials on the effectiveness of this medication in generalized anxiety disorder (GAD), and there are only a few case reports. We present a case of a 59-year-old female with a psychiatric history of GAD. The patient discontinued benzodiazepines after more than 7 years of daily treatment which led to rebound anxiety, benzodiazepine withdrawal symptoms, and suicidal ideation. She was psychiatrically hospitalized and started on gabapentin. Over the next 10 months of outpatient follow-up, she attempted to taper off gabapentin due to personal preference to limit medications. During this time, we observed a clear dose-response pattern of gabapentin on GAD symptoms. In the absence of controlled studies, these findings may offer important information about the effectiveness of gabapentin in GAD.
加巴喷丁常用于治疗焦虑症。然而,尚无关于该药物治疗广泛性焦虑症(GAD)有效性的随机对照试验,仅有少数病例报告。我们报告一例有GAD精神病史的59岁女性病例。该患者在每日服用苯二氮䓬类药物超过7年后停药,导致焦虑反弹、苯二氮䓬类药物戒断症状和自杀意念。她因精神问题住院并开始服用加巴喷丁。在接下来10个月的门诊随访中,由于个人偏好限制用药,她试图逐渐减少加巴喷丁的用量。在此期间,我们观察到加巴喷丁对GAD症状有明显的剂量反应模式。在缺乏对照研究的情况下,这些发现可能为加巴喷丁治疗GAD的有效性提供重要信息。