Suppr超能文献

加巴喷丁治疗广泛性焦虑障碍

Treatment of Generalized Anxiety Disorder with Gabapentin.

作者信息

Markota Matej, Morgan Robert J

机构信息

Department of Psychiatry and Psychology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

出版信息

Case Rep Psychiatry. 2017;2017:6045017. doi: 10.1155/2017/6045017. Epub 2017 Dec 14.

Abstract

Gabapentin is frequently used in the treatment of anxiety disorders. However, there are no randomized controlled trials on the effectiveness of this medication in generalized anxiety disorder (GAD), and there are only a few case reports. We present a case of a 59-year-old female with a psychiatric history of GAD. The patient discontinued benzodiazepines after more than 7 years of daily treatment which led to rebound anxiety, benzodiazepine withdrawal symptoms, and suicidal ideation. She was psychiatrically hospitalized and started on gabapentin. Over the next 10 months of outpatient follow-up, she attempted to taper off gabapentin due to personal preference to limit medications. During this time, we observed a clear dose-response pattern of gabapentin on GAD symptoms. In the absence of controlled studies, these findings may offer important information about the effectiveness of gabapentin in GAD.

摘要

加巴喷丁常用于治疗焦虑症。然而,尚无关于该药物治疗广泛性焦虑症(GAD)有效性的随机对照试验,仅有少数病例报告。我们报告一例有GAD精神病史的59岁女性病例。该患者在每日服用苯二氮䓬类药物超过7年后停药,导致焦虑反弹、苯二氮䓬类药物戒断症状和自杀意念。她因精神问题住院并开始服用加巴喷丁。在接下来10个月的门诊随访中,由于个人偏好限制用药,她试图逐渐减少加巴喷丁的用量。在此期间,我们观察到加巴喷丁对GAD症状有明显的剂量反应模式。在缺乏对照研究的情况下,这些发现可能为加巴喷丁治疗GAD的有效性提供重要信息。

相似文献

1
Treatment of Generalized Anxiety Disorder with Gabapentin.
Case Rep Psychiatry. 2017;2017:6045017. doi: 10.1155/2017/6045017. Epub 2017 Dec 14.
2
Gabapentin dependence and withdrawal requiring an 18-month taper in a patient with alcohol use disorder: a case report.
J Addict Dis. 2021 Oct-Dec;39(4):575-578. doi: 10.1080/10550887.2021.1907502. Epub 2021 Mar 30.
3
Gabapentin withdrawal syndrome in the presence of a taper.
Bipolar Disord. 2005 Jun;7(3):302-4. doi: 10.1111/j.1399-5618.2005.00200.x.
4
Withdrawal symptoms after gabapentin discontinuation.
Am J Health Syst Pharm. 2010 Jun 1;67(11):910-2. doi: 10.2146/ajhp090313.
5
Akathisia induced by gabapentin withdrawal.
Ann Pharmacother. 2011 Jun;45(6):e31. doi: 10.1345/aph.1Q057. Epub 2011 Jun 7.
9
Antidepressants for generalized anxiety disorder.
Cochrane Database Syst Rev. 2003(2):CD003592. doi: 10.1002/14651858.CD003592.
10
A rare case of bilateral lower extremity edema due to low dose gabapentin therapy in a young male patient.
J Basic Clin Pharm. 2015 Sep;6(4):117-8. doi: 10.4103/0976-0105.168053.

引用本文的文献

3
Adverse outcomes associated with concurrent gabapentin, opioid, and benzodiazepine utilization: A nested case-control study.
Lancet Reg Health Am. 2022 Jun 23;13:100302. doi: 10.1016/j.lana.2022.100302. eCollection 2022 Sep.
4
Psychiatric Uses of Gabapentin.
Innov Clin Neurosci. 2022 Jul-Sep;19(7-9):55-60.
5
Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale.
Mol Psychiatry. 2022 Mar;27(3):1339-1349. doi: 10.1038/s41380-021-01386-6. Epub 2021 Nov 24.
6
Pharmacotherapy for Anxiety Disorders: From First-Line Options to Treatment Resistance.
Focus (Am Psychiatr Publ). 2021 Jun;19(2):145-160. doi: 10.1176/appi.focus.20200048. Epub 2021 Jun 17.

本文引用的文献

1
Law enforcement-derived data on gabapentin diversion and misuse, 2002-2015: diversion rates and qualitative research findings.
Pharmacoepidemiol Drug Saf. 2017 Sep;26(9):1083-1086. doi: 10.1002/pds.4230. Epub 2017 May 10.
2
Gabapentin-Induced Bullous Pemphigoid.
J Am Osteopath Assoc. 2017 Mar 1;117(3):191-193. doi: 10.7556/jaoa.2017.034.
3
Benzodiazepine Use in Older Adults: Dangers, Management, and Alternative Therapies.
Mayo Clin Proc. 2016 Nov;91(11):1632-1639. doi: 10.1016/j.mayocp.2016.07.024.
4
Gabapentin Therapy in Psychiatric Disorders: A Systematic Review.
Prim Care Companion CNS Disord. 2015 Oct 22;17(5). doi: 10.4088/PCC.15r01821. eCollection 2015.
5
Gabapentin: Abuse, Dependence, and Withdrawal.
Ann Pharmacother. 2016 Mar;50(3):229-33. doi: 10.1177/1060028015620800. Epub 2015 Dec 31.
6
The role of gabapentin in the management of alcohol withdrawal and dependence.
Ann Pharmacother. 2015 Aug;49(8):897-906. doi: 10.1177/1060028015585849. Epub 2015 May 12.
7
Clinical outcomes in newer anticonvulsant overdose: a poison center observational study.
J Med Toxicol. 2014 Sep;10(3):254-60. doi: 10.1007/s13181-014-0384-5.
9
Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis.
Cell. 2009 Oct 16;139(2):380-92. doi: 10.1016/j.cell.2009.09.025. Epub 2009 Oct 8.
10
Gabapentin-induced delirium and dependence.
J Psychiatr Pract. 2009 Jul;15(4):314-9. doi: 10.1097/01.pra.0000358318.73684.df.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验