大鼠诱发胫前肌拉伤后坐骨神经功能指数的恢复时间。
Time to recovery of sciatic function index after induced tibialis anterior strain in rats.
作者信息
Mohammad Tasneem, Youssef Aliaa Rehan
机构信息
Department of Physical Therapy for Musculoskeletal Disorders and Surgery, Faculty of Physical Therapy, Cairo University, Giza, Egypt.
出版信息
Muscles Ligaments Tendons J. 2018 Jan 10;7(3):576-582. doi: 10.11138/mltj/2017.7.3.576. eCollection 2017 Jul-Sep.
BACKGROUND
Muscle strain is a common injury with a high recurrence rate. Due to the heterogeneity of strain injuries, experimental animals provide controlled and reproducible models to investigate such injuries. Sciatic Function Index (SFI) is a clinically feasible method to assess hind limb recovery in rodents after induced injuries.
OBJECTIVES
To investigate time to recovery of SFI after induced-strain in tibialis anterior (TA) muscle in rats.
METHODS
Sixteen adult male Wister rats were randomly and equally divided to a normal control group that received no intervention, and TA induced muscle strain group. Muscle strain was induced using an external weight that corresponded to 150% of the animal body weight. SFI was tested only once in the control group. For the muscle strain group, SFI was tested on the 1, 2, 3, 4, 7, 11, 20 and 24 days after strain induction.
RESULTS
Comparisons between group showed significant difference in SFI on the 1, 2, 3 and 4 days (p= 0.012, 0.012, 0.012 and 0.028, respectively).
CONCLUSIONS
In a rat animal model of TA induced muscle strain, functional recovery measured by SFI is evident on the 7 day post-injury, which corresponds to the sub-acute phase of injury.
LEVEL OF EVIDENCE
V.
背景
肌肉拉伤是一种常见损伤，复发率高。由于拉伤损伤的异质性，实验动物为研究此类损伤提供了可控且可重复的模型。坐骨神经功能指数（SFI）是评估啮齿动物诱导损伤后后肢恢复情况的一种临床可行方法。
目的
研究大鼠胫骨前肌（TA）诱导拉伤后SFI的恢复时间。
方法
将16只成年雄性Wister大鼠随机等分为未接受干预的正常对照组和TA诱导肌肉拉伤组。使用相当于动物体重150%的外部重量诱导肌肉拉伤。对照组仅进行一次SFI测试。对于肌肉拉伤组，在拉伤诱导后的第1、2、3、4、7、11、20和24天进行SFI测试。
结果
组间比较显示，在第1、2、3和4天SFI存在显著差异（分别为p = 0.012、0.012、0.012和0.028）。
结论
在TA诱导肌肉拉伤的大鼠动物模型中，损伤后第7天通过SFI测量的功能恢复明显，这与损伤的亚急性期相对应。
证据级别
V级。
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