促性腺激素类型和适应证对同源宫腔内人工授精成功的影响：来自 1251 个周期的研究及文献复习。
Effect of Gonadotropin Types and Indications on Homologous Intrauterine Insemination Success: A Study from 1251 Cycles and a Review of the Literature.
机构信息
ART and Reproductive Biology, University Hospital and School of Medicine, Picardie University Jules Verne, CHU Sud, 80054 Amiens, France.
PERITOX-INERIS Laboratory, CURS, Picardie University Jules Verne, CHU Sud, 80054 Amiens, France.
出版信息
Biomed Res Int. 2017;2017:3512784. doi: 10.1155/2017/3512784. Epub 2017 Dec 13.
OBJECTIVE
To evaluate the IUI success factors relative to controlled ovarian stimulation (COS) and infertility type, this retrospective cohort study included 1251 couples undergoing homologous IUI.
RESULTS
We achieved 13% clinical pregnancies and 11% live births. COS and infertility type do not have significant effect on IUI clinical outcomes with unstable intervention of various couples' parameters, including the female age, the IUI attempt rank, and the sperm quality.
CONCLUSION
Further, the COS used seemed a weak predictor for IUI success; therefore, the indications need more discussion, especially in unexplained infertility cases involving various factors. Indeed, the fourth IUI attempt, the female age over 40 years, and the total motile sperm count <5 × 10 were critical in decreasing the positive clinical outcomes of IUI. Those parameter cut-offs necessitate a larger analysis to give infertile couples more chances through IUI before carrying out other ART techniques.
目的
本回顾性队列研究纳入了 1251 对接受同源宫腔内人工授精（IUI）的夫妇，旨在评估与控制性卵巢刺激（COS）和不孕类型相关的 IUI 成功因素。
结果
我们获得了 13%的临床妊娠率和 11%的活产率。COS 和不孕类型对 IUI 临床结局没有显著影响，因为各种夫妇参数的干预不稳定，包括女性年龄、IUI 尝试次数和精子质量。
结论
此外，所用的 COS 似乎是 IUI 成功的一个较弱预测因素；因此，适应证需要更多讨论，特别是在涉及多种因素的不明原因不孕病例中。事实上，第四次 IUI 尝试、女性年龄超过 40 岁以及总活动精子计数<5×10 是降低 IUI 阳性临床结局的关键因素。这些参数的截止值需要进行更大的分析，以便在进行其他 ART 技术之前，让不孕夫妇通过 IUI 获得更多的机会。
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