Jiang Quan, Li Xiao-Rong, Wang Cheng-Kun, Cheng Juan, Tan Chao, Cui Tian-Tian, Lu Nan-Nan, James Tony D, Han Feng, Li Xin
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Chem Commun (Camb). 2018 Feb 15;54(15):1857-1860. doi: 10.1039/c7cc09135d.
This communication reports on a fluorescent probe (PPI-P) for imaging active peptidyl-prolyl cis/trans isomerases in live cells. PPI-P is capable of responding to both recombinant and cellular PPIases fluorogenically, and has been shown to specifically image active PPIases in live cells.
本通讯报道了一种用于在活细胞中对活性肽脯氨酰顺反异构酶进行成像的荧光探针（PPI-P）。PPI-P能够对重组的和细胞内的肽脯氨酰异构酶产生荧光响应，并且已被证明能够在活细胞中特异性地对活性肽脯氨酰异构酶进行成像。
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