Singh Harpreet, Kaur Kirandeep, Singh Mangaljeet, Kaur Gundeep, Singh Prabhjeet
Department of Biotechnology, Guru Nanak Dev University, Amritsar, India.
Department of Bioinformatics, Hans Raj Mahila Maha Vidyalaya, Jalandhar, India.
Front Plant Sci. 2020 Oct 22;11:585212. doi: 10.3389/fpls.2020.585212. eCollection 2020.
Cyclophilins constitute a family of ubiquitous proteins that bind cyclosporin A (CsA), an immunosuppressant drug. Several of these proteins possess peptidyl-prolyl isomerase (PPIase) activity that catalyzes the isomerization of the peptide bond preceding a proline residue, essential for correct folding of the proteins. Compared to prokaryotes and other eukaryotes studied until now, the cyclophilin gene families in plants exhibit considerable expansion. With few exceptions, the role of the majority of these proteins in plants is still a matter of conjecture. However, recent studies suggest that cyclophilins are highly versatile proteins with multiple functionalities, and regulate a plethora of growth and development processes in plants, ranging from hormone signaling to the stress response. The present review discusses the implications of cyclophilins in different facets of cellular processes, particularly in the context of plants, and provides a glimpse into the molecular mechanisms by which these proteins fine-tune the diverse physiological pathways.
亲环蛋白构成了一类普遍存在的蛋白质家族，它们能结合免疫抑制剂环孢菌素A（CsA）。其中几种蛋白质具有肽基脯氨酰异构酶（PPIase）活性，可催化脯氨酸残基之前肽键的异构化，这对蛋白质的正确折叠至关重要。与迄今为止研究的原核生物和其他真核生物相比，植物中的亲环蛋白基因家族有显著扩张。除了少数例外，这些蛋白质在植物中的大多数作用仍属推测。然而，最近的研究表明，亲环蛋白是具有多种功能的高度多功能蛋白质，并且在植物中调节大量的生长和发育过程，从激素信号传导到应激反应。本综述讨论了亲环蛋白在细胞过程不同方面的影响，特别是在植物背景下，并简要介绍了这些蛋白质微调各种生理途径的分子机制。
