Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden.
Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, 90187, Umeå, Sweden.
Arch Osteoporos. 2018 Jan 31;13(1):10. doi: 10.1007/s11657-018-0421-0.
This study revealed that a quick and simple estimation of protein intake was related to measures of bone density and area in 70-year-old individuals. Furthermore, these associations were mediated by muscle mass when investigating peripheral measurement sites such as arms and legs.
Recent evidence suggests that dietary protein is beneficial for bone health in older individuals, but less is known about the influence of muscle mass on this relationship. This cross-sectional study aimed to investigate associations among protein intake, bone health, and muscle mass in 2332 men and women aged 70 years.
Volumetric bone mineral density of the radius and tibia was measured using peripheral quantitative computed tomography. Using dual-energy X-ray absorptiometry, we measured areal bone mineral density (aBMD) at the L1-L4 vertebrae, radius, and femoral neck, together with appendicular lean mass. Participants reported their average meal size and proportion of meat/fish intake. Associations were investigated using multiple linear regression models, adjusted for multiple covariates.
Self-reported protein intake was associated with aBMD of the femoral neck (β = 0.082) and L1-L4 vertebrae (β = 0.063) in men (both p < 0.05) after adjusting for multiple covariates, including appendicular muscle mass. No significant association was detected among women. In addition, protein intake was associated with tibial cortical area (β = 0.08), periosteal circumference (β = 0.072), radial aBMD (β = 0.064), and trabecular area (β = 0.078) in men (all p < 0.05), although these associations were attenuated after adjustment for appendicular muscle mass (all p > 0.05).
Self-reported protein intake was associated with bone properties in 70-year-old men. The strength of these associations in peripheral bone sites may be partially mediated by muscle mass from protein intake.
本研究表明，对 70 岁个体进行快速、简单的蛋白质摄入量评估与骨密度和骨面积的测量值相关。此外，当研究手臂和腿部等外周测量部位时，这些关联可通过肌肉量来介导。
最近有证据表明，膳食蛋白质对老年人的骨骼健康有益，但对于肌肉量对这种关系的影响知之甚少。本横断面研究旨在调查 2332 名 70 岁男女的蛋白质摄入量、骨骼健康和肌肉量之间的关联。
使用外周定量计算机断层扫描测量桡骨和胫骨的容积骨矿物质密度。使用双能 X 射线吸收法，我们测量了 L1-L4 椎体、桡骨和股骨颈的面积骨矿物质密度（aBMD），以及四肢瘦体重。参与者报告了他们每餐的平均大小和肉类/鱼类摄入量的比例。使用多元线性回归模型，调整了多个协变量，对关联进行了调查。
在调整了包括四肢肌肉量在内的多个协变量后，男性自我报告的蛋白质摄入量与股骨颈（β=0.082）和 L1-L4 椎体（β=0.063）的 aBMD 相关（均 p<0.05）。在女性中未检测到显著关联。此外，蛋白质摄入量与男性的胫骨皮质面积（β=0.08）、骨膜周长（β=0.072）、桡骨 aBMD（β=0.064）和小梁面积（β=0.078）相关（均 p<0.05），但这些关联在调整四肢肌肉量后减弱（均 p>0.05）。
自我报告的蛋白质摄入量与 70 岁男性的骨骼特性相关。这些与外周骨骼部位相关的关联的强度可能部分由蛋白质摄入的肌肉量介导。
