Chinese Academy of Sciences, Key Lab of Urban Environment and Health, Institute of Urban Environment, Xiamen, 361021, People's Republic of China.
Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, People's Republic of China.
J Appl Toxicol. 2018 Jul;38(7):934-943. doi: 10.1002/jat.3595. Epub 2018 Feb 1.
Environmental chemicals (ECs) are drawing great attention to their effects on health and their toxicological mechanisms are being investigated. Long non-coding RNA (lncRNA) is a class of RNA with more than 200 nucleotides and does not have protein coding potential. Recently, it is emerging as a star molecule that participates in a wide range of physiological and pathological processes. It has been reported to be abnormally expressed in diseases. As an epigenetic factor, lncRNAs play an important role in the response of organisms to environmental stress. Their roles in the toxicity of ECs are being identified. Altered expression profiles of lncRNAs have been explored after exposure to ECs. Various kinds of ECs are reported to disturb the expression of lncRNAs in vitro and in vivo. Then, dysregulated lncRNAs can affect the expression of target genes directly or indirectly via regulating the level of microRNAs. The network among lncRNAs, microRNAs and mRNAs can initiate or impede specific signaling pathway and lead to adverse outcome upon exposure to ECs. Recovery of the lncRNAs level by overexpression or knockdown technology diminished the effect induced by ECs. In the review, biological roles of lncRNAs are depicted. The lncRNAs involved in the toxicology are summarized. Types of ECs that have been reported to affect the expression of lncRNAs are categorized. The interaction between various types of ECs and lncRNAs is discussed.
环境化学物质（ECs）因其对健康的影响而受到广泛关注，其毒理学机制也正在研究中。长链非编码 RNA（lncRNA）是一类具有 200 个核苷酸以上且没有蛋白编码潜能的 RNA。最近，它作为一种参与广泛的生理和病理过程的明星分子而崭露头角。已有报道称，lncRNA 在疾病中异常表达。作为一种表观遗传因子，lncRNA 在生物体对环境应激的反应中发挥着重要作用。它们在 ECs 毒性中的作用正在被确定。研究发现，lncRNA 的表达谱在暴露于 ECs 后发生改变。各种 ECs 被报道在体外和体内干扰 lncRNA 的表达。然后，失调的 lncRNA 可以通过调节 microRNA 的水平直接或间接地影响靶基因的表达。lncRNA、microRNA 和 mRNA 之间的网络可以启动或阻碍特定的信号通路，并导致在暴露于 ECs 时出现不良后果。通过过表达或敲低技术恢复 lncRNA 水平可以减轻 ECs 诱导的效应。在综述中，描绘了 lncRNA 的生物学作用。总结了参与毒理学的 lncRNA。对已报道的影响 lncRNA 表达的各种类型的 ECs 进行了分类。讨论了各种类型的 ECs 与 lncRNA 之间的相互作用。
