Coe J E, Ross M J
Endocrinology. 1986 May;118(5):2146-8. doi: 10.1210/endo-118-5-2146.
Injection of a synthetic progesterone, medroxyprogesterone acetate (MPA or Depo-ProveraR), a widely used contraceptive, into Chinese hamsters (Cricetulus griseus) induced a profound polyuria with daily output of dilute urine equal to about 50% body weight of the hamster. However, relatively normal ability for renal urine concentration was demonstrated by administration of exogenous vasopressin. Body weight did not increase during onset of MPA-induced polyuria or during interval of vasopressin-induced oliguria, suggesting that primary polydipsia was not etiologic. Administration of this steroid to Chinese hamsters was nontoxic, although these polyuric animals were unusually sensitive to water deprivation. This polyuria was not observed when progesterone alone was injected into Chinese hamsters or when MPA was given to other related hamster species (Armenian, Syrian, Turkish or Djzungarian). The MPA-injected Chinese hamster represents a unique model of vasopressin sensitive diabetes insipidus induced by a steroid in a species-specific fashion.
向中国仓鼠（黑线仓鼠）注射一种合成孕激素醋酸甲羟孕酮（MPA或Depo - ProveraR），这是一种广泛使用的避孕药，会引发严重的多尿症，仓鼠每日排出的稀释尿液量约等于其体重的50%。然而，通过给予外源性血管加压素证明其肾脏尿液浓缩能力相对正常。在MPA诱导的多尿症发作期间或血管加压素诱导的少尿期，体重并未增加，这表明原发性烦渴并非病因。向中国仓鼠注射这种类固醇无毒，尽管这些多尿的动物对缺水异常敏感。当单独向中国仓鼠注射孕酮或向其他相关仓鼠物种（亚美尼亚仓鼠、叙利亚仓鼠、土耳其仓鼠或准噶尔仓鼠）给予MPA时，并未观察到这种多尿症。注射MPA的中国仓鼠代表了一种独特的模型，即由类固醇以物种特异性方式诱导的血管加压素敏感性尿崩症。
