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他莫昔芬与甲羟孕酮联合抗雌激素疗法在妇科肿瘤学中的应用方式及效果

Modalities and results of a combined anti-estrogenic therapy by means of tamoxifen and medroxyprogesterone in gynecologic cancerology.

作者信息

Bonte J, Janssens J P, Ide P

出版信息

Eur J Gynaecol Oncol. 1986;7(1):45-50.

PMID:2938955
Abstract

In the therapeutic schemes of the hormone-dependent gynecologic cancers, the combined administration of tamoxifen and medroxyprogesterone, generally, scores better results. The highly hormone-dependent tumors (ER+, PgR+) respond very well to a combined, simultaneous treatment. The strictly hormone-dependent (ER+, PgR-) and the potentially hormone-dependent (ER-, PgR-) tumors seem to be most efficiently treated by means of a combined, successive scheme.

摘要

在激素依赖性妇科癌症的治疗方案中,通常他莫昔芬与甲羟孕酮联合使用能取得更好的效果。高度激素依赖性肿瘤(雌激素受体阳性、孕激素受体阳性)对联合同步治疗反应良好。严格激素依赖性肿瘤(雌激素受体阳性、孕激素受体阴性)和潜在激素依赖性肿瘤(雌激素受体阴性、孕激素受体阴性)似乎通过联合序贯方案治疗最为有效。

相似文献

1
Modalities and results of a combined anti-estrogenic therapy by means of tamoxifen and medroxyprogesterone in gynecologic cancerology.他莫昔芬与甲羟孕酮联合抗雌激素疗法在妇科肿瘤学中的应用方式及效果
Eur J Gynaecol Oncol. 1986;7(1):45-50.
2
Cyclical use of tamoxifen and high-dose medroxyprogesterone acetate in advanced estrogen receptor positive breast cancer.他莫昔芬与大剂量醋酸甲羟孕酮在晚期雌激素受体阳性乳腺癌中的周期性应用
Breast Cancer Res Treat. 1990 Nov;17(1):45-50. doi: 10.1007/BF01812683.
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Influence of tamoxifen-medroxyprogesterone sequential therapy on estrogen and progesterone receptor contents of breast cancer.他莫昔芬-甲羟孕酮序贯疗法对乳腺癌雌激素和孕激素受体含量的影响。
Jpn J Cancer Res. 1989 Mar;80(3):244-8. doi: 10.1111/j.1349-7006.1989.tb02300.x.
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New trends in the use of medroxyprogesterone acetate as a chemotherapeutic agent in gynecologic malignancies.醋酸甲羟孕酮作为妇科恶性肿瘤化疗药物使用的新趋势。
Eur J Gynaecol Oncol. 1992;13(2):113-23.
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[Response of estrogen and progesterone receptors to treatment with large doses of progestogen (depo-provera) in endometrial cancer].[子宫内膜癌中雌激素和孕激素受体对大剂量孕激素(醋酸甲羟孕酮)治疗的反应]
Zentralbl Gynakol. 1990;112(17):1111-5.
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Sequential alternate administration of tamoxifen and medroxyprogesterone acetate in advanced breast cancer: clinical-biological randomized study.他莫昔芬与醋酸甲羟孕酮序贯交替给药治疗晚期乳腺癌:临床生物学随机研究
Tumori. 1990 Apr 30;76(2):190-5. doi: 10.1177/030089169007600208.
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Effective sequential administration of tamoxifen and medroxyprogesterone acetate for 7,12-dimethylbenz[a-anthracene-induced rat mammary tumors in relation to hormone receptors.他莫昔芬与醋酸甲羟孕酮序贯给药对7,12-二甲基苯并[a]蒽诱导的大鼠乳腺肿瘤的影响及其与激素受体的关系
Jpn J Cancer Res. 1985 Nov;76(11):1120-5.
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[Adjuvant hormone therapy in endometrial carcinoma: medroxyprogesterone acetate versus tamoxifen-medroxyprogesterone acetate sequential therapy].
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Treatment of recurrent or metastatic poorly differentiated adenocarcinoma of the endometrium with tamoxifen and medroxyprogesterone acetate.他莫昔芬与醋酸甲羟孕酮治疗复发性或转移性子宫内膜低分化腺癌
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[Hormonotherapy of metastatic breast cancer with tamoxifen and medroxyprogesterone acetate. Randomized trial comparing alternating sequences with successive applications].[他莫昔芬与醋酸甲羟孕酮对转移性乳腺癌的激素治疗。交替用药方案与连续用药方案比较的随机试验]
Bull Cancer. 1986;73(2):148-54.