Gudmundsson J A, Nillius S J, Bergquist C
Fertil Steril. 1986 May;45(5):617-23. doi: 10.1016/s0015-0282(16)49331-3.
Forty-seven woman volunteers used a new highly potent stimulatory analog of the hypothalamic gonadotropin-releasing hormone (GnRH) for contraception. The superagonist nafarelin acetate, D-Nal(2)6-GnRH, was administered intranasally in one daily dose of 125 micrograms to 25 women and 250 micrograms to 22 women. Ovulation was consistently inhibited during 261 of 262 treatment months. No pregnancy occurred during 222 months in which no additional contraceptives were used. The mean plasma estradiol level after 6 months of treatment was 162 pmol/l. The predominant bleeding pattern was oligomenorrhea. Three women on the lower dose and six women on the higher dose discontinued the trial prematurely, mainly because of hot flushes. No serious side effects were reported. Ovulatory menstruations returned after a median time of 43 days after discontinuation of therapy. Daily intranasal nafarelin treatment for inhibition of ovulation proved to be an effective and rapidly reversible method of contraception.
47名女性志愿者使用了一种新型的、高效的下丘脑促性腺激素释放激素（GnRH）刺激类似物进行避孕。超激动剂醋酸那法瑞林，即D-Nal(2)6-GnRH，以每日一次的剂量经鼻给药，25名女性的剂量为125微克，22名女性的剂量为250微克。在262个治疗月中的261个月里，排卵持续受到抑制。在222个月未使用其他避孕措施的期间内未发生妊娠。治疗6个月后的平均血浆雌二醇水平为162 pmol/l。主要的出血模式为月经过少。3名低剂量组女性和6名高剂量组女性提前终止了试验，主要原因是潮热。未报告严重副作用。停药后排卵性月经恢复的中位时间为43天。每日经鼻给予那法瑞林以抑制排卵被证明是一种有效且可逆性快速的避孕方法。
