Gudmundsson J A, Lundkvist O, Bergquist C, Lindgren A, Nillius S J
Fertil Steril. 1987 Jul;48(1):52-6. doi: 10.1016/s0015-0282(16)59289-9.
Light and electron microscopic studies were performed on endometrial curettage specimens from 27 women after 6 months of contraceptive treatment with continuous intranasal gonadotropin hormone-releasing hormone (GnRH) superagonist. The GnRH superagonist nafarelin acetate (D-Nal[2]6-GnRH) was used in single daily doses of 125 or 250 micrograms. Ovulation was inhibited during all but one of the 159 treatment months. No pregnancies occurred. In 6 women with fairly regular bleedings, the endometrium displayed weak to normal proliferation. Twenty women developed oligomenorrhea or amenorrhea, 16 of them had inactive endometrium, 1 had weakly proliferative endometrium, and 3 endometrial biopsies were too sparse for adequate evaluation. One woman reported repeated episodes of heavy uterine bleedings. The endometrial biopsy from this woman showed weak proliferation. No signs of endometrial hyperplasia were observed. Generally, the electron microscopy showed signs of low metabolic activity and weak protein synthesis. Thus, long-term continuous treatment with nafarelin acetate for inhibition of ovulation does not appear to have untoward effects on the endometrium.
对27名接受持续鼻内注射促性腺激素释放激素（GnRH）超激动剂避孕治疗6个月后的女性的子宫内膜刮宫标本进行了光镜和电镜研究。GnRH超激动剂醋酸那法瑞林（D-Nal[2]6-GnRH）每日单次剂量为125或250微克。在159个治疗月中，除1个月外，其余时间均抑制了排卵。未发生妊娠。6名月经相当规律的女性，其子宫内膜表现为轻度至正常增殖。20名女性出现月经过少或闭经，其中16名子宫内膜无活性，1名子宫内膜轻度增殖，3份子宫内膜活检标本组织太少无法进行充分评估。1名女性报告反复出现大量子宫出血。该女性的子宫内膜活检显示增殖较弱。未观察到子宫内膜增生的迹象。总体而言，电镜显示代谢活性低和蛋白质合成弱的迹象。因此，长期持续使用醋酸那法瑞林抑制排卵似乎对子宫内膜没有不良影响。
