Boxall E H, Tarlow M J
J Med Virol. 1986 Mar;18(3):255-60. doi: 10.1002/jmv.1890180307.
A study was carried out to evaluate the efficacy of hepatitis B vaccine in interrupting perinatal transmission of hepatitis B virus from carrier mothers to their babies. A four-dose schedule was used. Eight of nine babies of e antigen carrier mothers became actively immune when immunisations were started within 48 hr of birth. Effectiveness was reduced if immunisation was delayed. This report includes results from a total of 32 babies, the longest period of follow-up being 2 years. The success of this scheme is comparable to that of more intensive prophylaxis of immunoglobulin either alone or combined with vaccine and should be seriously considered for the babies of all hepatitis B carrier mothers.
开展了一项研究以评估乙肝疫苗在阻断乙肝病毒从携带病毒的母亲围产期传播给其婴儿方面的效果。采用了四剂接种方案。e抗原携带母亲的九名婴儿中有八名在出生后48小时内开始免疫接种时产生了主动免疫。如果免疫接种延迟，效果会降低。本报告包括总共32名婴儿的结果，最长随访期为2年。该方案的成功率与单独使用或与疫苗联合使用更强效的免疫球蛋白预防方案相当，所有乙肝携带母亲的婴儿都应认真考虑采用该方案。
