Hefti A
SSO Schweiz Monatsschr Zahnheilkd. 1979 Jul;89(7):689-98.
An animal model was presented to study periodontal disease in Osborne-Mendel rats with depressed indigenous oral flora. In connection with the inoculation of an erythromycin-resistant strain A. viscosus Ny 1 E after 40 experimental days only the animals showed plaque formation, bleeding from the gingival sulcus upon gentle probing and severe alveolar bone loss. 56% sucrose in the diet counteracted the establishment of A. viscosus Ny 1 E in dental plaques. As a consequence plaque formation, gingival bleeding and bone loss diminished. Plaque formation, gingival bleeding and bone loss were correlated.
提出了一种动物模型，用于研究口腔固有菌群受抑制的奥斯本-孟德尔大鼠的牙周病。在实验40天后接种耐红霉素的粘性放线菌菌株Ny 1 E，只有这些动物出现了菌斑形成、轻探牙龈沟时出血以及严重的牙槽骨丧失。饮食中56%的蔗糖可抑制粘性放线菌Ny 1 E在牙菌斑中的定植。结果，菌斑形成、牙龈出血和骨质流失减少。菌斑形成、牙龈出血和骨质流失之间存在相关性。
