聚对二甲苯（聚氯对二甲苯）对内耳的组织病理学影响。
Histopathological Effects of Parylene C (poly-chloro-p-xylylene) in the Inner Ear.
作者信息
Cevizci Raşit, Düzlü Mehmet, Uyar Pınar Göçün, Karamert Recep, Bezgin Selin Üstün, Tutar Hakan, Göksu Nebil, Bayazıt Yıldırım Ahmet
机构信息
Department of Otorhinolaryngology, İstanbul Medipol University School of Medicine, İstanbul, Turkey.
Department of Otorhinolaryngology, Gazi University School of Medicine, Ankara, Turkey.
出版信息
Turk Arch Otorhinolaryngol. 2016 Jun;54(2):53-57. doi: 10.5152/tao.2016.1511. Epub 2016 Jun 1.
OBJECTIVE
To assess the histopathological effects of parylene C (PC) (poly-chloro-p-xylylene) in the inner ear.
METHODS
Nine adult Dunkin Hartley guinea pigs (500-600 g) were included in the study. PC pieces were inserted into the cochlea in the right ear of the animals (study group). The round windows were punctured in the left ears comprised the control group. After three months, the animals were sacrificed, and the dissected temporal bones were examined under a light microscope.
RESULTS
No significant difference was revealed between the study and control groups regarding histopathological findings such as perineural congestion, perineural inflammation, neural fibrosis, number of ganglion cells, edema, and degeneration of ganglion cells (p>0.05).
CONCLUSION
PC did not cause any additional histopathologic damage in the cochlea. This finding may be promising regarding the use of PC in cochlear implant electrodes as an alternative to silicon materials in the future.
目的
评估聚对二甲苯（聚氯对二甲苯，PC）对内耳的组织病理学影响。
方法
本研究纳入9只成年Dunkin Hartley豚鼠（体重500 - 600克）。将PC片插入动物右耳的耳蜗（研究组）。在作为对照组的左耳刺破圆窗。三个月后，处死动物，对解剖后的颞骨进行光学显微镜检查。
结果
在神经周围充血、神经周围炎症、神经纤维化、神经节细胞数量、水肿以及神经节细胞变性等组织病理学表现方面，研究组与对照组之间未发现显著差异（p>0.05）。
结论
PC未对耳蜗造成任何额外的组织病理学损伤。这一发现对于未来将PC用作耳蜗植入电极中硅材料的替代品可能具有前景。
Zotero 插件